merck millipore,默克密理博,MABT201,Anti-Integrin alpha5 (Preservative Free) Antibody, clone SNAKA51

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	ICC, WB, ACT	M	Protein G Purified	Monoclonal Antibody

描述
产品目录编号	MABT201
描述	Anti-Integrin alpha5 (Preservative Free) Antibody, clone SNAKA51
Alternate Names	CD51 Integrin alpha-V Vitronectin receptor subunit alpha
背景信息	Integrins are a family of dimeric, transmembrane proteins that mediate cell-cell and extracellular matrix adhesion. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. The integrin family is composed of at least 15 alpha and 8 beta subunits that may form over twenty different alpha-beta non-covalently bound dimeric combinations on the cell surface. The alpha subunits all have some homology to each other, as do the beta subunits. Both of the subunits contribute to the binding of the ligand. Integrin alpha subunits contain seven weak sequence repeats in the N-terminal region, which may be important in ligand binding, and have been predicted to fold cooperatively into a single beta-propeller domain with seven beta-sheets. The α5/β1 integrin, also termed VLA5 or CD49e, is identical to the fibronectin receptor and mediates the adhesion of cells to fibronectin.

产品信息
格式	Protein G Purified
控制	HeLa cells
演示	Purified mouse monoclonal IgG2aκ in buffer containing PBS without preservatives.

应用
应用	Detect Integrin alpha5 (Preservative Free) using this Anti-Integrin alpha5 (Preservative Free) Antibody, clone SNAKA51 validated for use in Western Blotting, Activity Assay, ICC.
主要应用	Immunocytochemistry Western Blotting Activity Assay
应用说明	Activity Assay: A representative lot of this antibody converts alpha5 beta1 integrin into a ligand competant form and promotes fibronectin binding (Clark, K., et al. (2005). J Cell Sci. 118(Pt 2):291-300.). Immunocytochemistry Analysis: A representative lot of this antibody detected Integin alpha 5 in Primary human foreskin fibroblasts (hFF) (Clark, K., et al. (2005). J Cell Sci. 118(Pt 2):291-300.; Valdembri, D., et al. (2009). PLoS Biol. 7(1):e25.).

生物信息
免疫原品种	Whole cells corresponding to human Integrin alpha5.
克隆	SNAKA51
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
同种型	IgG_2α
品种反应性	Human
Species Reactivity Note	Demonstrated to react with Human.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_001138472
基因符号	ITGAV; MSK8; VNRA
纯化方法	Protein G purified
UniProt编号	P06756

产品使用声明
质量保证	Evaluated by Flow Cytometry in HeLa cell treated with fibronectin. Flow Cytometry Analysis: 1 µg of this antibody detected Integrin alpha5 in 0.5X10^6 HeLa cells.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MABT201,Anti-Integrin alpha5 (Preservative Free) Antibody, clone SNAKA51

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