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品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 MABS61 描述 Anti-PARG Antibody, clone D8B10 Alternate Names - poly(ADP-ribose) glycohydrolase 60 kDa isoform
- poly (ADP-ribose) glycohydrolase
背景信息 Poly(ADP-ribose) glycohydrolase (PARG) is an enzyme possessing both endo- and exoglycosidase activity against poly (ADP-ribose) (PARP), rapidly degrading PARP to release large quantities of free ADP-ribose. PARG is involved in several cellular processes including; apoptosis, DNA repair, cell cycle progression, cell survival and cellular differentiation. During apoptosis, PARG is cleaved by caspase-3 suggesting that PARG activity is regulated during this process. Although encoded by one gene, PARG is present in different cellular localizations as different isoforms: Isoform 1 (111 kDa) is present in the nucleus, Isoform 2 (102 kDA) is in the cytoplasm and Isoform 3 (99 kDa) is mitochondrial. Studies have indicated a critical role for PARG isoform 1 in the quality of sperm chromatin, and subsequent embryonic survival. 产品信息 格式 Purified 控制 - Jurkat cell lysate
演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-PARG Antibody, clone D8B10 is an antibody against PARG for use in WB & IP. 主要应用 - Western Blotting
生物信息 免疫原品种 Histidine-tagged recombinant protein corresponding to human PARG. 表位 Unknown 克隆 D8B10 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 0 同种型 IgG2aκ 品种反应性 Human Species Reactivity Note Reacts with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_003622
Entrez基因汇总 Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. [provided by RefSeq]. 基因符号 - PARG99
- PARG
纯化方法 Protein G UniProt编号 - Q86W56
UniProt汇总 FUNCTION: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells.
CATALYTIC ACTIVITY: Hydrolyzes poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.
SUBCELLULAR LOCATION: Isoform 1: Nucleus.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm.
TISSUE SPECIFICTY: Ubiquitously expressed.
SEQUENCE SIMILARITIES: Belongs to the poly(ADP-ribose) glycohydrolase family.产品使用声明 质量保证 Evaluated by Western Blot in Jurkat cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected PARG on 10 µg of Jurkat cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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