merck millipore,默克密理博,MABE578,Anti-RCC1, clone EPR5857, Rabbit Monoclonal Antibody

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merck millipore,默克密理博,MABE578,Anti-RCC1, clone EPR5857, Rabbit Monoclonal Antibody
产品名称：Anti-RCC1, clone EPR5857, Rabbit Monoclonal Antibody
产品型号：MABE578
This Anti-RCC1, clone EPR5857, Rabbit Monoclonal Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of RCC1.

merck millipore,默克密理博,MABE578,Anti-RCC1, clone EPR5857, Rabbit Monoclonal Antibody

产品介绍

merck millipore,默克密理博,MABE578,Anti-RCC1, clone EPR5857, Rabbit Monoclonal Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABE578
描述	Anti-RCC1, clone EPR5857, Rabbit Monoclonal Antibody
Alternate Names	Chromosome condensation protein 1 Regulator of chromosome condensation Cell cycle regulatory protein
背景信息	The Regulator of Chromosome Condensation 1 (RCC1) is a guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. RCC1 is a critical cell cycle regulator, and it interacts with Ran, a nuclear GTP-binding protein. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Studies have shown that RCC1 plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly. RCC1 is involved in regulating the onset of chromosome condensation during S phase. The RCC1 protein binds both to the nucleosomes and double-stranded DNA. The RCC1 complex acts as a guanine-nucleotide dissociation stimulator (GDS) by promoting the loss of bound GDP and the uptake of fresh GTP. Mutations in RCC1 have been assiciated with Raynaud disease.

产品信息
格式	Unpurified
演示	Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

应用
应用	This Anti-RCC1, clone EPR5857, Rabbit Monoclonal Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of RCC1.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:100-250 dilution from a representative lot detected RCC1 in human bladder carcinoma tissue. Produced in collaboration with Epitomics™

生物信息
免疫原品种	Synthetic peptide corresponding to human RCC1.
克隆	EPR5857
浓缩	Please refer to lot specific datasheet.
宿主	Rabbit
同种型	IgG
品种反应性	Human
Species Reactivity Note	Human
抗体类型	Monoclonal Antibody
基因符号	CHC1 RCC1
纯化方法	Unpurified
UniProt编号	P18754

产品使用声明
质量保证	Evaluated by Western Blotting in A431, HeLa, Jurkat, and HEK293 cell lysates. Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected RCC1 in A431, HeLa, Jurkat, and HEK293 cell lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.