merck millipore,默克密理愽
  • merck millipore,默克密理博,444968,InSolution™ MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem

  • merck millipore,默克密理博,444968,InSolution™ MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem

    产品名称：InSolution™ MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem
    产品型号：444968
    The InSolution™ MEK1/2 Inhibitor III, PD0325901, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation  More>>

    merck millipore,默克密理博,444968,InSolution™ MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,444968,InSolution™ MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₆H₁₄F₃IN₂O₄391210-10-9
    描述
    概述 A cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumor in vivo.
    产品目录编号 444968
    品牌系列 Calbiochem®
    同义词 PD 0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD325901
    参考
    参考 Barrett, S.D., et al. 2008. Bioorg. Med. Chem. Lett. 18, 6501.
    Leyton, J., et al. 2008. Mol. Cancer Ther. 7, 3112.
    Silva, J., et al. 2008. PLoS Biol. 6, 2237.
    Ying, Q.L., et al. 2008. Nature 453, 519.
    Bain, J., et al. 2007. Biochem. J. 408, 297.
    Solit, D.B., et al. 2006. Nature 439, 358.
    产品信息
    CAS号 391210-10-9
    形式 Liquid
    配方 A 50 mM (5 mg/207 µl) solution of MEK1/2 Inhibitor III, PD0325901 (Cat. No. 444966) in DMSO.
    Hill配方 C₁₆H₁₄F₃IN₂O₄
    化学配方 C₁₆H₁₄F₃IN₂O₄
    Molar Mass 482.2
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    储存和货运信息
    货运代码 Dry Ice Only
    毒性 Regulatory Review
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following initial thaw, aliquot and freeze (-20°C).
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,444968,InSolution™ MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem

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