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merck millipore,默克密理博,567569,Spautin-1 - Calbiochem
产品名称：Spautin-1 - Calbiochem
产品型号：567569
A quinazolin compound that acts as a specific and potent inhibitor of autophagy and promotes Vps34 PI 3-kinase complex degradation by blocking the activity of USP 10 (IC₅₀ = 580 nM) and USP 13 (IC₅₀ = More>>
merck millipore,默克密理博,567569,Spautin-1 - Calbiochem
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重要规格表
经验配方 C₁₅H₁₁F₂N₃ 描述 概述 A quinazolin compound that acts as a specific and potent inhibitor of autophagy and promotes Vps34 PI 3-kinase complex degradation by blocking the activity of USP 10 (IC50 = 580 nM) and USP 13 (IC50 = 690 nM) deubiquitinating enzymes. However, it does not affect the lipid kinase activity of Vps34. Also shown to reduce the level of cytoplasmic and nuclear p53. Sensitizes breast cancer cell lines (BCAP37, MCF-7, and BT549) to apoptosis under conditions of nutritional deprivation. Also shown to inhibit etoposide-induced cell death in Bax/Bak double knockout (DKO) cells. Normal cell lines (e.g., MDCK cells) do not undergo autophagy in the presence of Spautin-1. 产品目录编号 567569 品牌系列 Calbiochem®
同义词 C43, 6-fluoro-N-[4-fluorobenzyl]quinazolin-4-amine, Specific and Potent AUtophagy Inhibitor 1, Autophagy Inhibitor II 参考 参考 Lui, J., et al. 2011, Cell. 147, 223. 产品信息 形式 Off-white solid Hill配方 C₁₅H₁₁F₂N₃ 化学配方 C₁₅H₁₁F₂N₃ Molar Mass 271.26 结构配方图像 生物信息 纯度 ≥99% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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