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merck millipore,默克密理博,MABS172,Anti-FABP4 Antibody, clone EPR3579, Rabbit,MABS172
产品名称：Anti-FABP4 Antibody, clone EPR3579, Rabbit, MABS172
产品型号：MABS172
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-FABP4 Antibody, clone EPR3579, Rabbit detects l More>>
merck millipore,默克密理博,MABS172,Anti-FABP4 Antibody, clone EPR3579, Rabbit,MABS172
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Diluted Culture Supernatant Monoclonal Antibody 描述 产品目录编号 MABS172 描述 Anti-FABP4 Antibody, clone EPR3579, Rabbit | MABS172 Alternate Names - fatty acid-binding protein, adipocyte
- fatty acid binding protein 4, adipocyte
- Adipocyte lipid-binding protein
- Adipocyte-type fatty acid-binding protein
- Fatty acid-binding protein 4
背景信息 Fatty acid binding proteins (FABPs) are proteins that reversibly bind fatty acids and other lipids. So far, nine tissue-specific cytoplasmic FABPs have been identified. Functions attributable to these lipid binding proteins remain unclear, but data are presented that indicate physiological roles in 1) fatty acid transport, esterification, and oxidation, 2) steroidogenesis, and 3) retinoid uptake, retinaldehyde reduction, and retinol esterification (1). Adipose tissue FABP (FABP4) binds both long chain fatty acids and retinoic acid (2). It delivers retinoic acid to nulear trans-acting proteins, thereby modulates genes coding for key proteins
involved in lipid metabolism or differentiation. FABP4 is closely associated with metabolic syndrome, type 2 diabetes, and atheroscelerosis (3,4).
产品信息 格式 Diluted Culture Supernatant 控制 - Human adipose and fetal heart tissue lysates
演示 Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. 应用 应用 Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-FABP4 Antibody, clone EPR3579, Rabbit detects level of FABP4 & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic peptide corresponding to human FABP4. 克隆 EPR3579 宿主 Rabbit 同种型 IgG 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. 抗体类型 Monoclonal Antibody Entrez基因编号 - P15090
基因符号 - ALBP
- A-FABP
- aP2
- AFABP
纯化方法 Unpurified UniProt编号 - P15090
UniProt汇总 FUNCTION: Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus By similarity.
SUBUNIT STRUCTURE: Homodimer. Interacts with PPARG By similarity. Monomer.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export By similarity.
DOMAIN: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
SEQUENCE SIMILARITIES: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
产品使用声明 质量保证 Evaluated by Western Blot in human adipose and fetal heart tissue lysates.
Western Blot Analysis: A 1:1,000-1:5,000 dilution of this antibody detected FABP4 in human adipose and fetal heart tissue lysates.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. 包装信息 数量 100 µL
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