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merck millipore,默克密理博,ABE541,Anti-phospho-STAT2 (Tyr689) Antibody
产品名称：Anti-phospho-STAT2 (Tyr689) Antibody
产品型号：ABE541
Anti-phospho-STAT2 (Tyr689) Antibody is an antibody against phospho-STAT2 (Tyr689) for use in Immunoprecipitation.
merck millipore,默克密理博,ABE541,Anti-phospho-STAT2 (Tyr689) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE541 描述 Anti-phospho-STAT2 (Tyr689) Antibody Alternate Names - p113
背景信息 The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia. STAT2 (113 kDa), originally purified from the nuclei of a-interferon-treated cells, is critical to the transcriptional responses induced by type I interferons, IFN-alpha/beta. Knockout mice with a targeted disruption of STAT2 exhibit greater susceptibility to viral infection and altered responses to Type I interferons. Stat2 is rapidly activated by phosphorylation at Tyr690 in response to stimulation by IFN-alpha/beta via assocations with receptor-bound Jak kinases. 产品信息 格式 Affinity Purified 控制 - Untreated and IFN alpha/gamma treated HeLa cell lysate.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-phospho-STAT2 (Tyr689) Antibody is an antibody against phospho-STAT2 (Tyr689) for use in Immunoprecipitation. 主要应用 - Western Blotting
应用说明 Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated phospho-STAT2 (Tyr689) from IFN alpha treated HeLa cell lysate. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to mouse STAT2 phosphorylated at Tyr689. 表位 Phosphorylated Tyr689. 宿主 Rabbit 特异性 This antibody recognizes STAT2 phosphorylated at Tyr689. 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with Human. Predicted to react with Mouse based on 100% sequence homology. Other homologies: Rat (89% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_064347
基因符号 - STAT2
纯化方法 Affinity purified UniProt编号 - Q9WVL2
产品使用声明 质量保证 Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: A 1:200 dilution of this antibody detected phospho-STAT2 (Tyr689) in 10 µg of IFN alpha/gamma treated HeLa cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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