merck millipore,默克密理博,AB15369,Anti-DUF1220 Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	AB15369
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-DUF1220 Antibody
背景信息	Extreme gene duplication is a major source of evolutionary novelty. A genome-wide survey of gene copy number variation among human and great ape lineages revealed that the most striking human lineage–specific amplification was due to an unknown gene, MGC8902, which is predicted to encode multiple copies of a protein domain of unknown function (DUF1220). Sequences encoding these domains are virtually all primate-specific, show signs of positive selection, and are increasingly amplified generally as a function of a species' evolutionary proximity to humans, where the greatest number of copies (212) is found. DUF1220 domains are highly expressed in brain regions associated with higher cognitive function, and in brain show neuron-specific expression preferentially in cell bodies and dendrites (Popesco et al. 2006).

产品信息
格式	Affinity Purified
演示	Liquid in PBS containing approximately 0.1% sodium azide.

应用
应用	Anti-DUF1220 Antibody detects level of DUF1220 & has been published & validated for use in WB, IH.
主要应用	Immunohistochemistry Western Blotting
应用说明	Western blot: 1:1,000-1:2,500 on human brain. Immunohistochemistry on human cerebellum. Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	Synthetic peptide from primate DUF1220.
宿主	Rabbit
特异性	DUF1220. The antibody recognizes a protein of ~36 kDa in lysates from human heart, brain, spleen, and small intestine. The band can be blocked in all tissues by incubating the antibody with the immunogen peptide. By immunohistochemistry the antibody recognizes DUF1220 in the cerebellum, preferential expression was observed in Purkinje cells, where signals were restricted to cell bodies (cytoplasm) and dendrites. In addition to labeling in the cerebellum, neuron-specific DUF1220 signals were present in the cortical layers of the hippocampus. DUF1220 domains were also abundantly expressed in neurons within the neocortex (frontal, parietal, occipital, and temporal lobes) (See Popesco et al. 2006).
品种反应性	Human
抗体类型	Polyclonal Antibody
纯化方法	Immunoaffinity purified

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.

包装信息
数量	100 µL

merck millipore,默克密理博,AB15369,Anti-DUF1220 Antibody

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