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merck millipore,默克密理博,MABN636,Anti-LRRK2 Antibody, clone 8G10
产品名称：Anti-LRRK2 Antibody, clone 8G10
产品型号：MABN636
Detect LRRK2 using this mouse monoclonal antibody, Anti-LRRK2 Antibody, clone 8G10 validated for use in western blotting & IHC.
merck millipore,默克密理博,MABN636,Anti-LRRK2 Antibody, clone 8G10
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABN636 描述 Anti-LRRK2 Antibody, clone 8G10 Alternate Names - Dardarin
- Leucine-rich repeat serine/threonine-protein kinase 2
背景信息 Leucine-rich repeat kinase 2 (LRRK2) is a 2,527 amino acid protein encoded by the PARK8 gene and belonging to the ROCO family of proteins. This protein family is characterized as having a unique interaction between the Roc domain and the intrinsic GTPase activity along with a COR domain. LRRK2 consists of 5 different domains; a tyrosine kinase-like MAPKKK-related domain, WD40 propeller motif repeats, a Roc (Ras-like small GTPase family) domain, a COR (C-terminal of Roc) domain, and an LRRK. LRRK2 is mainly localized to the cytoplasm and expression within tissue is most highly observed within the brain. It is found in lower levels within the liver, heart, lung, skeletal muscles, placenta, pancreas, and kidney. The exact function of LRRK2 is unknown; however mutations to any of the five domains are the most commonly known causes of Parkinson’s disease, both familial and sporadic. Further study of this protein may lead to a better understanding of the disease’s pathogenesis, as well as potential therapeutic markers. 产品信息 格式 Purified 控制 - Human brain tissue lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect LRRK2 using this mouse monoclonal antibody, Anti-LRRK2 Antibody, clone 8G10 validated for use in western blotting & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected LRRK2 in human thalamus tissue lysate. 生物信息 免疫原品种 Recombinant protein corresponding to human LRRK2. 克隆 8G10 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody does not seem to recognize LRRK2 in mouse embryonic fibroblasts cell lysates, but recognizes LRRK2 in human lymphoblast cell lysates. 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. Other Homologies: Rat and Mouse (82% sequence homology). 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_940980
基因符号 - PARK8
- LRRK2
纯化方法 Protein G purified UniProt编号 - Q5S007
产品使用声明 质量保证 Evaluated by Western Blotting in human brain tissue lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected LRRK2 in 10 µg of human brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,540500,Purvalanol A - CAS 212844-53-6 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,MABF350,Anti-CD284 (TLR4) (human) Antibody, PE, clone HTA125
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