- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 ABC457 描述 Anti-dUTPase Antibody Alternate Names - dUTPase
- Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
- UTPase
- dUTP pyrophosphatase
背景信息 dUTPase, also known as dUTP pyrophosphatase, and encoded by the gene DUT, is a critical enzyme involved in nucleotide metabolism for the production of dUMP, the immediate precursor of thymidine nucleotides. dUTPase normally can also function to decrease the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA and cause mutations. dUTPase is localized to the nucleus and mitochondrial locations. dUTPase is expressed in numerous tissues and has multiple isoforms. Some isoforms are constitutively expressed while others match DNA replication cycles. Because dUTPase plays a pivotal role in regulating cellular dUTP pools, this enzyme could have profound effects on the efficacy of agents that target thymidylate biosynthesis and dUTPase expression is being examined as a prognostic marker for overall survival and response to therapy in colon and other cancers where thymidylate therapy is used. 产品信息 格式 Purified 演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-dUTPase Antibody is a highly specific rabbit polyclonal antibody, that targets dUTPase & has been tested in western blotting. 主要应用 - Western Blotting
应用说明 Western Blotting Analysis: 2 µg/mL from a representative lot detected dUTPase in 10 µg of A431, HEK293, and HeLa cell lysates and human placenta tissue lysate.
Western Blotting Analysis: A representative lot from an independent laboratory detected dUTPase in MDA-MB231, MCF-7, H184B5F5/M10 cell lysate (Hu, C. M., et al. (2012). Cancer Cell. 22(1):36-50.).生物信息 免疫原品种 Recombinant protein corresponding to human dUTPase. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001020419
基因符号 - DUT
纯化方法 Protein A purified UniProt编号 - P33316
产品使用声明 质量保证 Evaluated by Western Blotting in MDA-MB-231 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected dUTPase in 10 µg of MDA-MB-231 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,MAB367,Anti-Muscarinic Acetylcholine Receptor m2 Antibody, clone M2-2-B3
下一件merck millipore产品：merck millipore,默克密理博,107660,乳糖
相关产品
merck millipore,默克密理博,GF407,HumanKine FGF basic, Human Recombinant Xeno-Free
merck millipore,默克密理博,05-861,Anti-vWF (von Willebrand Factor) Antibody, clone GMA-022
merck millipore,默克密理博,AP126P,Chicken Anti-Mouse IgG Antibody, HRP conjugate
merck millipore,默克密理博,71746,D-Tube™ Dialyzer Mega, 20 ml, MWCO 6-8 kDa
merck millipore,默克密理博,MAB367,Anti-Muscarinic Acetylcholine Receptor m2 Antibody, clone M2-2-B3
merck millipore,默克密理博,107660,乳糖
merck millipore,默克密理博,SLGV004SL,Millex-GV，0.22 µm，PVDF，4 mm，环氧乙烷灭菌
merck millipore,默克密理博,540500,Purvalanol A - CAS 212844-53-6 - Calbiochem
merck millipore,默克密理博,MABN636,Anti-LRRK2 Antibody, clone 8G10
merck millipore,默克密理博,MABF350,Anti-CD284 (TLR4) (human) Antibody, PE, clone HTA125