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merck millipore,默克密理博,05-861,Anti-vWF (von Willebrand Factor) Antibody, clone GMA-022
产品名称：Anti-vWF (von Willebrand Factor) Antibody, clone GMA-022
产品型号：05-861
Anti-vWF (von Willebrand Factor) Antibody, clone GMA-022 is an antibody against vWF (von Willebrand Factor) for use in WB.
merck millipore,默克密理博,05-861,Anti-vWF (von Willebrand Factor) Antibody, clone GMA-022
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 05-861 品牌系列 Upstate
商名 - Upstate
描述 Anti-vWF (von Willebrand Factor) Antibody, clone GMA-022 产品信息 格式 Purified 应用 应用 Anti-vWF (von Willebrand Factor) Antibody, clone GMA-022 is an antibody against vWF (von Willebrand Factor) for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Purified human von Willebrand Factor 克隆 GMA-022 宿主 Mouse 特异性 von Willebrand Factor 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000552
Entrez基因汇总 The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. 基因符号 - F8VWF
- VWF
- F8
- vWF
- VWD
纯化方法 DEAE purified UniProt编号 - P04275
UniProt汇总 FUNCTION: SwissProt: P04275 # Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
SIZE: 2813 amino acids; 309299 Da
SUBUNIT: Multimeric. Interacts with F8.
SUBCELLULAR LOCATION: Secreted. Note=Localized to storage granules.
TISSUE SPECIFICITY: Plasma.
DOMAIN: SwissProt: P04275 The von Willebrand antigen 2 is required for multimerization of VWF and for its targeting to storage granules.
PTM: All cysteine residues are involved in intrachain or interchain disulfide bonds.
DISEASE: SwissProt: P04275 # Defects in VWF are associated with various forms of von Willebrand disease (VWD) [MIM:193400, 277480]. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.). Type I VWD is associated with a deficiency of VWF; type II by normal to decreased plasma level of VWF; type III by a virtual absence of VWF. There are subtypes (A to H) of type II VWD; for example: type IIA is characterized by the absence of VWF high molecular weight multimers in plasma.
SIMILARITY: Contains 1 CTCK (C-terminal cystine knot-like) domain. & Contains 4 TIL (trypsin inhibitory-like) domains. & Contains 3 VWFA domains. & Contains 3 VWFC domains. & Contains 4 VWFD domains.产品使用声明 质量保证 Routinely evaluated by immunoblot 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 100 µg
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