merck millipore,默克密理愽
  • merck millipore,默克密理博,MABN466,Anti-Ankyrin-G Antibody, clone N106/36

  • merck millipore,默克密理博,MABN466,Anti-Ankyrin-G Antibody, clone N106/36

    产品名称：Anti-Ankyrin-G Antibody, clone N106/36
    产品型号：MABN466
    Anti-Ankyrin-G Antibody, clone N106/36 is a highly specific mouse monoclonal antibody & that targets Ankyrin & has been tested in IHC.

    merck millipore,默克密理博,MABN466,Anti-Ankyrin-G Antibody, clone N106/36

  • 产品介绍
  • merck millipore,默克密理博,MABN466,Anti-Ankyrin-G Antibody, clone N106/36

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RIHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABN466
    描述 Anti-Ankyrin-G Antibody, clone N106/36
    Alternate Names
    • Ankyrin-G
    • Ankyrin-3
    • ANK-3
    背景信息 Ankyrins are a family of spectrin-binding proteins that couple the spectrin/actin cytoskeletal network to the cytoplasmic domains of integral membrane proteins which include channels such as the anion exchanger, voltage-dependent sodium channel, and the Na/K ATPase, as well as neuronal cell adhesion molecules related to L1. In the nervous system, three different ankyrins are known to exist; ankyrinB, ankyrinG, and ankyrinR. All three ankyrins contain an N-terminal membrane binding domain, an internal domain capable of binding spectrin, and a C-terminal regulatory domain which is the target of alternative splicing. AnkyrinB, the predominant neuronal ankyrin includes two isoforms of ~220 kDa and ~440 kDa. The ~220 kDa alternatively spliced isoform is the major form present in the adult brain, while the ~440 kDa form is preferentially expressed in the developing neonatal brain. Three forms of ankyrinG (~190 kDa, ~270 kDa, ~480 kDa) are localized in axonal initial segments and the nodes of Ranvier of myelinated axons where fluxes of action potential occur and ion channels are enriched. Ankyrins comprise ~0.5%-1% of the total membrane protein in the adult vertebrate brain.
    产品信息
    格式 Purified
    控制
    • Rat hippocampus tissue
    演示 Purified mouse monoclonal IgG1κ in 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Ankyrin-G Antibody, clone N106/36 is a highly specific mouse monoclonal antibody & that targets Ankyrin & has been tested in IHC.
    主要应用
    • Immunohistochemistry
    应用说明 Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Ankyrin-G in rat cerebral cortex tissue.

    Immunohistochemistry Analysis: A representative lot detected Ankyrin-G in rat optic nerve tissue.

    Immunofluorescence Analysis: A representative lot detected Ankyrin-G in adult rat cortex tissue.

    Immunofluorescence Analysis: A representative lot from an independent laboratory detected Ankyrin-G in a rat model of TLE mEC layer II neurons (Hargus, N. J., et al. (2011). Neurobiol Dis. 41(2):361-376.)
    生物信息
    免疫原品种 Recombinant protein corresponding to human Ankyrin-G.
    克隆 N106/36
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 Rat
    Species Reactivity Note Demonstrated to react with Rat. Other homologies: Human (92% sequence homology), and Mouse (87% sequence homology).
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_066267
    基因符号
    • ANK3
    纯化方法 Protein G purified
    UniProt编号
    • Q12955
    产品使用声明
    质量保证 Evaluated by Immunohistochemistry in rat hippocampus tissue.

    Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Ankyrin-G in rat hippocampus tissue.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABN466,Anti-Ankyrin-G Antibody, clone N106/36

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