merck millipore,默克密理愽
  • merck millipore,默克密理博,400084,HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem

  • merck millipore,默克密理博,400084,HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem

    产品名称：HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem
    产品型号：400084


    merck millipore,默克密理博,400084,HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,400084,HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₁H₁₆ClN₃O385786-48-1
    描述
    概述 A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.
    产品目录编号 400084
    品牌系列 Calbiochem®
    参考
    参考 Smirnova, N.A., et al. 2010. Chem. Biol. 4, 380.
    产品信息
    CAS号 385786-48-1
    形式 Tan solid
    Hill配方 C₂₁H₁₆ClN₃O
    化学配方 C₂₁H₁₆ClN₃O
    Molar Mass 377.82
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,400084,HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem

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