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merck millipore,默克密理博,MABN391,Anti-FIS1 Antibody, Clone 4D1.1
产品名称：Anti-FIS1 Antibody, Clone 4D1.1
产品型号：MABN391
This Anti-FIS1 Antibody, Clone 4D1.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of FIS1.
merck millipore,默克密理博,MABN391,Anti-FIS1 Antibody, Clone 4D1.1
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H WB M Purified Monoclonal Antibody 描述 产品目录编号 MABN391 描述 Anti-FIS1 Antibody, Clone 4D1.1 Alternate Names - Short name=TPR repeat protein 11
- FIS-1
- FIS 1
- FIS1 homolog
- Mitochondrial fission 1 protein
- hFis1
- hFis-1hFis 1
- Tetratricopeptide repeat protein 11
背景信息 FIS1 or TTC11, or FIS1 homolog (hFis1), or Tetratricopeptide repeat protein 11 (TPR repeat protein 11) or Mitochondrial fission 1 protein is an interesting member of mitochondrial essential proteins. FIS1 is encoded by the nuclear gene FIS1 and is a key player in mitochondrial dynamics. In eukaryotic cells, the shape of mitochondria can be tuned to various physiological conditions by a balance of fusion and fission processes termed mitochondrial dynamics. Mitochondrial dynamics control not only the morphology but also the function of mitochondria, and therefore is crucial in many aspects of a cell's life. Thus there is a dynamic balance between fission and fusion events that can promote health and normal cell growth or when dysfunctional mitochondrial dynamics have been implicated in a variety of human diseases including cancer. Human FIS1 a mitochondrial, outer membrane localized, adaptor protein that is critical to recruiting the cellular machinery needed for mitochondrial fission or fusion. FIS1 is inserted into the mitochondrial outer membrane via a C-terminal transmembrane domain that, along with a short basic segment, is essential for its targeting to the mitochondria. Overexpression of FIS1 in human cells causes mitochondrial fragmentation and aggregation. FIS1 interacts with the dynamin-related GTPase DLP1/DRP1, and along with other adaptor proteins such as MDV1, MFF, and MiD, the dynamin-related proteins form spirals around constricted sites on mitochondria and assist in the fission of it. In addition to mitochondria, FIS1 also mediates peroxisome fission via the interaction with DLP1 as well. EMD-Millipore’s Anti-FIS1 rabbit polyclonal antibody has been tested in western blot on HeLa cell extracts and in immunohistochemistry on human brain tissue sections. 产品信息 格式 Purified 演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-FIS1 Antibody, Clone 4D1.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of FIS1. 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected FIS1 in human and rat cerebral cortex tissue. 生物信息 免疫原品种 GST-tagged recombinant protein corresponding to Human FIS1. 克隆 4D1.1 浓缩 Please refer to lot specific datasheet. 宿主 Mouse 同种型 IgG2bκ 品种反应性 RatHuman Species Reactivity Note Human, Rat. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_057152
基因符号 - CGI-135
- TTC11
- FIS1
纯化方法 Protein G purified UniProt编号 - Q9Y3D6
产品使用声明 质量保证 Evaluated by Western Blotting in Raji cell lysate.
Western Blotting Analysis: A 1 µg/mL dilution of this antibody detected FIS1 in 10 µg of Raji cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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