- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,05-1513,Anti-FXR2 Antibody, clone A42
产品名称：Anti-FXR2 Antibody, clone A42
产品型号：05-1513
Use Anti-FXR2 Antibody, clone A42 (Mouse Monoclonal Antibody) validated in WB, IP, ICC to detect FXR2 also known as fragile X mental retardation syndrome related protein 2.
merck millipore,默克密理博,05-1513,Anti-FXR2 Antibody, clone A42
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-1513 描述 Anti-FXR2 Antibody, clone A42 Alternate Names - fragile X-mental retardation 1-like 2
- fragile X mental retardation syndrome related protein 2
- fragile X mental retardation, autosomal homolog 2
背景信息 Fragile X Mental Retardation Syndrome is the most common form of hereditary mental retardation, and is caused by defects in the FMR1 gene. FMR1 is an RNA-binding protein and the syndrome results from lack of expression of FMR1 or expression of a mutant protein that is impaired in RNA binding. FXR2 is very similar to FMR1 (60% identity). FXR2 encodes a 74 kDa protein which, like FMR1, contains two KH domains, has the capacity to bind RNA and is localized to the cytoplasm. The FXR2 gene is located on human chromosome 17 at 17p13.1. In addition, FMR1 and FXR2 interact tightly with the recently described autosomal homolog FXR1. Each of these three proteins is capable of forming heterodimers with the others, and each can also form homodimers. FXR1 and FXR2 are thus likely to play important roles in the function of FMR1 and in the pathogenesis of the Fragile X Mental Retardation Syndrome. 产品信息 格式 Purified 控制 - Jurkat cell lysate
演示 Purified mouse monoclonal IgG1κ buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Use Anti-FXR2 Antibody, clone A42 (Mouse Monoclonal Antibody) validated in WB, IP, ICC to detect FXR2 also known as fragile X mental retardation syndrome related protein 2. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunoprecipitation: Siomi, M.C., et al. (1996). Mol Cell Biol. 16(7):3825-3832
Immunocytochemistry: Wan, L., et al. (2000). Mol Cel Biol. 20(22) 8536-8547
生物信息 免疫原品种 His-tagged recombinant protein corresponding to human FXR2. 表位 Unknown 克隆 A42 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes FXR2. 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Proven to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_004851.2
Entrez基因汇总 The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome. 基因符号 - FMR1L2
- FXR2
纯化方法 Protein G purfied UniProt编号 - P51116
UniProt汇总 FUNCTION: RNA-binding protein.
SUBUNIT STURCUTRE: Interacts with FMR1 and FXR1. Interacts with CYFIP2 but not with CYFIP1. Interacts with TDRD3.
SUBCELLULAR LOCATION: Cytoplasm.
SEQUENCE SIMILARITIES: Belongs to the FMR1 family.产品使用声明 质量保证 Evaluated by Western Blot in jurkat cell lysate.
Western Blot Analysis: 0.1 µg/ml of this antibody detected FXR2 on 10 µg of jurkat cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,UFC910024,Amicon Ultra-15，PLHK Ultracel-PL 超滤膜，100 kDa
下一件merck millipore产品：merck millipore,默克密理博,MAB8906,Anti-Measles Antibody, nucleoprotein, clone 83KKII
相关产品
merck millipore,默克密理博,MABN391,Anti-FIS1 Antibody, Clone 4D1.1
merck millipore,默克密理博,05-557,Anti-Notch 1 Antibody, clone 8G10
merck millipore,默克密理博,05-23-2401,Calcitonin, Salmon
merck millipore,默克密理博,6310-OP,OmniPur MOPS - CAS 1132-61-2 - Calbiochem
merck millipore,默克密理博,UFC910024,Amicon Ultra-15，PLHK Ultracel-PL 超滤膜，100 kDa
merck millipore,默克密理博,MAB8906,Anti-Measles Antibody, nucleoprotein, clone 83KKII
merck millipore,默克密理博,SF-1301,CDKN1A; Human, Cyanine 3 RNA Detection Probe,SmartFlare
