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经验配方 CAS号 C₁₂H₁₅N₃O₂S · 2HCl 113276-94-1 描述 概述 A potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits protein kinase A (Ki = 1.2 µM), myosin light chain kinase (Ki = 68 µM), protein kinase C (Ki = 15 µM), and protein kinase G (Ki = 480 nM). 产品目录编号 371958 品牌系列 Calbiochem®
同义词 N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor I 参考 参考 Ido, M., et al. 1991. Br. J. Cancer 64, 1103.
Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523.
Inagaki, M., et al. 1986. Mol. Pharmacol. 29, 577.
Hidaka, H., et al. 1984. Biochemistry 23, 5036.产品信息 CAS号 113276-94-1 具有ATP竞争性 Y 形式 Lyophilized Hill配方 C₁₂H₁₅N₃O₂S · 2HCl 化学配方 C₁₂H₁₅N₃O₂S · 2HCl Molar Mass 338.3 可逆 Y 结构配方图像 生物信息 主靶 MLCK 主靶Ki 68 µM against MLCK 纯度 >95% by TLC 理化信息 细胞可渗透 Y 溶解度 H₂O 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
无需冷冻 No
特殊指南 Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
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