merck millipore,默克密理愽
  • merck millipore,默克密理博,MABN381,Anti-APP-C99 Antibody, clone mC99(1-7)

  • merck millipore,默克密理博,MABN381,Anti-APP-C99 Antibody, clone mC99(1-7)

    产品名称：Anti-APP-C99 Antibody, clone mC99(1-7)
    产品型号：MABN381
    Anti-APP-C99 Antibody, clone mC99(1-7) is a highly specific mouse monoclonal antibody, that targets APP & has been tested in western blotting, IP, ICC & IHC.

    merck millipore,默克密理博,MABN381,Anti-APP-C99 Antibody, clone mC99(1-7)

  • 产品介绍
  • merck millipore,默克密理博,MABN381,Anti-APP-C99 Antibody, clone mC99(1-7)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HIHC, WB, ICCMAscitesMonoclonal Antibody
    描述
    产品目录编号 MABN381
    描述 Anti-APP-C99 Antibody, clone mC99(1-7)
    Alternate Names
    • PN-II
    • Amyloid beta A4 protein
    • ABPP
    • APPI
    • APP
    • Alzheimer disease amyloid protein
    • Cerebral vascular amyloid peptide
    • CVAP
    • PreA4
    • Protease nexin-II
    背景信息 Amyloid Precursor Protein (APP) is expressed in the brain, kidney, heart, and spleen of fetal tissues; it is induced during neuronal differentiation. The most-substantiated role for APP is in synaptic formation and repair; its expression is upregulated during neuronal differentiation and after neural injury. In adult brain, highest expression of APP is found in the frontal lobe of the cortex. Moderate expression is observed in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Defects in APP are a cause of autosomal dominant Alzheimer's disease (AD). UP on intracerebroventricular injection of this antibody, A beta levels significantly decreased in the brain of APPPS1 mouse model of AD. A related antibody, Cat. No. MABN380, Anti-APP-C99, clone mC99(70-80) was raised against a slightly different region of the same APP-C99 protein.
    产品信息
    格式 Ascites
    演示 Mouse monoclonal IgGκ in ascites containing 0.05% sodium azide.
    应用
    应用 Anti-APP-C99 Antibody, clone mC99(1-7) is a highly specific mouse monoclonal antibody, that targets APP & has been tested in western blotting, IP, ICC & IHC.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    应用说明 Immunoprecipitation Analysis: A representative lot immunoprecipitated APP-C99 in HEK APPSwe cell lysate (Houacine, J., et al. (2012). Neurobiol Aging. 33(11):2704-2714.).

    Immunohistochemistry Analysis: A representative lot detected APP-C99 in APPS1 mice and in human Alzheimer brain tissues
    (Houacine, J., et al. (2012). Neurobiol Aging. 33(11):2704-2714.).

    Immunofluoresence Anlaysis: A representative lot detected APP-C99 in HEK APPSwe cells (Houacine, J., et al. (2012). Neurobiol Aging. 33(11):2704-2714.).
    生物信息
    免疫原品种 Recombinant protein corresponding to Human APP-C99.
    克隆 mC99(1-7)
    宿主 Mouse
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with Human and Mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_000475
    基因符号
    • AD1
    • APP
    • A4
    纯化方法 Unpurified
    UniProt编号
    • P05067
    产品使用声明
    质量保证 Evaluated by Western Blotting in DAPT treated HEK293 cell lysate.

    Western Blotting Anlaysis: A 1:2,000 dilution of this antibody detected APP-C99 in 10 µg of DAPT treated HEK293 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MABN381,Anti-APP-C99 Antibody, clone mC99(1-7)

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