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描述 产品目录编号 14-500M 品牌系列 Upstate
商名 - Upstate
描述 Flt-3 Protein, active, 250 µg 概述 N-terminal GST tagged, recombinant human Flt3, amino acids 564 - end 应用 应用 Active, N-terminal GST tagged, recombinant human Flt3, amino acids 564 -end. For use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed in Sf21 cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_004119.2
Entrez基因汇总 This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. 基因符号 - STK1
- FLT3
- STK-1
- CD135
- FLK2
- OTTHUMP00000042340
蛋白靶 Flt3 纯化方法 Glutathione Sepharose™ 靶子系列 TK UniProt编号 - P36888
UniProt汇总 FUNCTION: SwissProt: P36888 # Receptor for the FL cytokine. Has a tyrosine-protein kinase activity.
SIZE: 993 amino acids; 112903 Da
SUBUNIT: Interacts with FIZ1 following ligand activation (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Bone marrow cells.
SIMILARITY: SwissProt: P36888 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of Abltide 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-500) and in bulk (cat# 14-500-K).
上一件merck millipore产品：merck millipore,默克密理博,14-600M,TAK1-TAB1 fusion Protein, active, 250 µg
下一件merck millipore产品：merck millipore,默克密理博,MAHFC1H60,MultiScreen 收集板 APFC，不透明，100 µL 孔
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