merck millipore,默克密理博,MABN330,Anti-Glucagon (non-Oxyntomodulin) Antibody, clone 12D4.14.11

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, H	ELISA	M	Purified	Monoclonal Antibody

描述
产品目录编号	MABN330
描述	Anti-Glucagon (non-Oxyntomodulin) Antibody, clone 12D4.14.11
背景信息	Glucagon is a hormone that is proteolytically cleaved into at least eight different functional peptides. It is produced by pancreatic cells and it has binding sites in the brain, intestines, and liver, among other tissues. Glucagon is secreted in response to hypoglycemia. Through the combined activation of Gsα- and Gq-coupled transmembrane receptors and their downstream signaling pathways, glucagon stimulates the release of glucose from the liver into the bloodstream. One important mechanism underlying this process is the activation of protein kinase A (PKA). PKA signals result in increased transcription of phosphoenolpyruvate carboxykinase, which encodes the rate-limiting enzyme in the production of glucose from noncarbohydrate substrates. PKA signals may also increase the breakdown of glycogen, and suppress glycolysis. Glucagon may also engage in calcium-dependent signaling via PLC. The importance of glucagon in regulating glucose homeostasis, in conjunction with insulin, is underscored by findings that glucagon and glucagon receptor signaling are disrupted in type II diabetes.

产品信息
格式	Purified
控制	Normal rat pancreas tissue
演示	Purified mouse monoclonal IgG3κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Anti-Glucagon (non-Oxyntomodulin) Antibody, clone 12D4.14.11 is an antibody against Glucagon (non-Oxyntomodulin) for use in IHC(P), Immunofluorescence, ELISA, Multiplexing.
主要应用	ELISA
应用说明	Immunofluorescence Analysis: A 1:1,500 dilution from a representative lot detected Glucagon (non-Oxyntomodulin) in alpha cells in the Islets of Langerhans in normal rat pancreas sections. Direct ELISA Analysis: A representative lot detected Glucagon (non-Oxyntomodulin) in direct ELISA. Luminex® Analysis: A representative lot detected Glucagon (non-Oxyntomodulin) in Luminex Assay.

生物信息
免疫原品种	Linear peptide corresponding to human Glucagon.
克隆	12D4.14.11
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
同种型	IgG3κ
品种反应性	RatHuman
Species Reactivity Note	Demonstrated to react with Human and Rat.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_002045
基因符号	GCG
纯化方法	Protein G purified
UniProt编号	P01275

产品使用声明
质量保证	Evaluated by Immunohistochemistry in normal rat pancreas tissue. Immunohistochemistry Analysis: A 1:2,000 dilution of this antibody detected Glucagon (non-Oxyntomodulin) in normal rat pancreas tissue.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MABN330,Anti-Glucagon (non-Oxyntomodulin) Antibody, clone 12D4.14.11

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