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品种反应性 主要应用 宿主 格式 抗体类型 Chp, H, Po WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN63 描述 Anti-GPx1 Antibody Alternate Names - Cellular glutathione peroxidase
背景信息 Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides. It functions in the protection of cells against oxidative damage and can be found mainly in the cytosol of mammalian cells. GPx is unusual in its content of a selenocysteine residue in its active site. Animal models have demonistrated a role for GPx1 in protection against oxidative stress in neurons, cataract formation, and heart failure. 产品信息 格式 Affinity Purified 控制 - THP-1 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-GPx1 Antibody is an antibody against GPx1 for use in WB. 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected GPx1 in human brain tissues. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human GPx1 near the C-terminus. 表位 Near C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes GPx1 near the C-terminus. 品种反应性 ChimpanzeeHumanPig Species Reactivity Note Demonstrated to react with Human. Predicted to react with Porcine and Chimpanzee based on 100% sequence homology. Other homologies: Rat (92% sequence homology) and Mouse (71% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_000572
Entrez基因汇总 This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. 基因符号 - GPX1
纯化方法 Affinity purified UniProt编号 - P07203
UniProt汇总 FUNCTION: Protects the hemoglobin in erythrocytes from oxidative breakdown.
CATALYTIC ACTIVITY: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
SUBUNIT STRUCTURE: Homotetramer.
SUBCELLULAR LOCATION: Cytoplasm.
SEQUENCE SIMILARITIES: Belongs to the glutathione peroxidase family.产品使用声明 质量保证 Evaluated by Western Blot in THP-1 cell lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected GPx1 on 10 µg of THP-1 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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