merck millipore,默克密理博,GF103,Soluble Tumor Necrosis Factor Receptor Type I Protein, Recombinant human

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merck millipore,默克密理博,GF103,Soluble Tumor Necrosis Factor Receptor Type I Protein, Recombinant human
产品名称：Soluble Tumor Necrosis Factor Receptor Type I Protein, Recombinant human
产品型号：GF103
The Tumor Necrosis Factor receptor type I (or TNF-receptor I protein) is also referred to as p60.

merck millipore,默克密理博,GF103,Soluble Tumor Necrosis Factor Receptor Type I Protein, Recombinant human

产品介绍

merck millipore,默克密理博,GF103,Soluble Tumor Necrosis Factor Receptor Type I Protein, Recombinant human

重要规格表

主要应用	品种	来源	纯度
CULT	Human	E.coli	Greater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of sTNF receptor.

描述
产品目录编号	GF103
品牌系列	Chemicon®
商名	Chemicon
描述	Soluble Tumor Necrosis Factor Receptor Type I Protein, Recombinant human
概述	Tumor Necrosis Factor receptor type I (TNF-receptor I) is also referred to as p60. The p60 form of the receptor is primarily expressed on epithelial cells. Human soluble TNF receptor Type I (sTNF-receptor I) is a 18.3 kDa protein containing 162 amino acid residues comprising the extra cellular domain of TNF.
Alternate Names	sTNF-receptor I

产品信息
演示	Sterile filtered and then the protein was lyophilized from a solution of 5 mM Tris, pH 8.0.

应用
应用	The Tumor Necrosis Factor receptor type I (or TNF-receptor I protein) is also referred to as p60.
主要应用	Cell Culture

生物信息
纯度	Greater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of sTNF receptor.
来源	E.coli
品种	Human
特异活性	BIOLOGICAL ACTIVITY: <br /><br />GF103 is fully biologically active as determined by its inhibitory effect of the TNF-alpha mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of recombinant human TNF-alpha, is 0.05 μg/ml.
Entrez基因编号	NM_001065.2
Entrez基因汇总	The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
基因符号	MGC19588 TNFRSF1A TNFR1 TNF-R1 TNFR-I p60 CD120a p55-R TNF-RI TNFR60 TNF-R55 TNFAR TBP1 TNFR55 TNF-R-I FPF TNF-R p55
UniProt编号	P19438
UniProt汇总	FUNCTION: SwissProt: P19438 # Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. SIZE: 455 amino acids; 50495 Da SUBUNIT: Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Secreted. DOMAIN: SwissProt: P19438 The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE. & Both the cytoplasmic membrane-proximal region and the C- terminal region containing the death domain are involved in the interaction with TRPC4AP (By similarity). PTM: The soluble form is produced from the membrane form by proteolytic processing. DISEASE: "SwissProt: P19438 # Defects in TNFRSF1A are the cause of familial hibernian fever (FHF) [MIM:142680]; also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is an autosomal dominant disease characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia." SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	The lyophilized protein while stable for a few weeks at room temperature, is best stored at -20°C for up to 12 months after date of receipt. Reconstitute in 5 mM Tris, pH 8.0 to a concentration of 0.1-1.0 mg/mL. Reconstituted sTNF receptor can be diluted into other buffered solutions or stored at -20°C in undiluted aliquots for up to 3-6 months. Freeze/thaw cycles will result in significant loss of activity.

储存和货运信息

存储条件

The lyophilized protein while stable for a few weeks at room temperature, is best stored at -20°C for up to 12 months after date of receipt. Reconstitute in 5 mM Tris, pH 8.0 to a concentration of 0.1-1.0 mg/mL. Reconstituted sTNF receptor can be diluted into other buffered solutions or stored at -20°C in undiluted aliquots for up to 3-6 months. Freeze/thaw cycles will result in significant loss of activity.