merck millipore,默克密理博,05-840,Anti-IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1

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merck millipore,默克密理博,05-840,Anti-IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1
产品名称：Anti-IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1
产品型号：05-840
Anti-IDO (Indoleamine 2, 3-Dioxygenase) Antibody, clone 10.1 is an antibody against IDO (Indoleamine 2 for use in IC & WB.

merck millipore,默克密理博,05-840,Anti-IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1

产品介绍

merck millipore,默克密理博,05-840,Anti-IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M, H	WB, ICC	M	Purified	Monoclonal Antibody

描述
产品目录编号	05-840
Replaces	04-1056
品牌系列	Upstate
商名	Upstate
描述	Anti-IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1
Alternate Names	IDO1 indoleamine-pyrrole 2,3 dioxygenase indole 2,3-dioxygenase Indoleamine-pyrrole 2,3-dioxygenase Indoleamine 2,3-dioxygenase
背景信息	Indoleamine 2,3-dioxygenase (IDO) is an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO may be involved in the suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.

产品信息
格式	Purified
控制	Human IFN-gamma stimulated HeLa cell lysates, IFN gamma stimulated human peripheral blood lymphocytes.
演示	Purified mouse monoclonal IgG in buffer containing 70% storage buffer 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide and 30% glycerol.

应用
应用	Anti-IDO (Indoleamine 2, 3-Dioxygenase) Antibody, clone 10.1 is an antibody against IDO (Indoleamine 2 for use in IC & WB.
主要应用	Western Blotting Immunocytochemistry
应用说明	Immunocytochemistry: A previous lot was used by an independent laboratory in Phoenix cells transfected with an expression vector. Immunohistochemistry: A previous lot of this antibody was used to detect IDO in human retina, primary eye tumor and metastatic liver tumor tissue sections (Chen, P.W., et al. Experimental Eye Research 85(2007) 617-625).

生物信息
免疫原品种	GST fusion protein corresponding to residues 78-184 of human Indoleamine 2,3- Dioxygenase (IDO). Clone 10.1.
克隆	10.1
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	Recognizes IDO (Indoleamine 2,3- Dioxygenase), Mr 42kDa.
同种型	IgG
品种反应性	MouseHuman
Species Reactivity Note	Human and mouse.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_002155
Entrez基因汇总	Gamma-interferon (IFNG; MIM 147570) has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and Chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase (INDO; EC 1.13.11.42). This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine.[supplied by OMIM]
基因符号	IDO INDO
纯化方法	Protein G purfied
UniProt编号	P14902
UniProt汇总	FUNCTION: SwissProt: P14902 # Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. COFACTOR: Binds 1 heme group per subunit. SIZE: 403 amino acids; 45326 Da SIMILARITY: SwissProt: P14902 ## Belongs to the indoleamine 2,3-dioxygenase family.

产品使用声明
质量保证	Routinely evaluated by Western Blot on untreated and IFNgamma treated (24 hrs) Hela lysates. Western Blot Analysis: 1:500 dilution of this lot detected IDO on 10 ug of untreated and IFN gamma treated Hela lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.

Handling Recommendations:
Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.