merck millipore,默克密理愽
  • merck millipore,默克密理博,MABF62,Anti-Tim3 Antibody, clone 2E2

  • merck millipore,默克密理博,MABF62,Anti-Tim3 Antibody, clone 2E2

    产品名称：Anti-Tim3 Antibody, clone 2E2
    产品型号：MABF62
    Anti-Tim3 Antibody, clone 2E2 detects level of Tim3 & has been published & validated for use in WB, FC.

    merck millipore,默克密理博,MABF62,Anti-Tim3 Antibody, clone 2E2

  • 产品介绍
  • merck millipore,默克密理博,MABF62,Anti-Tim3 Antibody, clone 2E2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABF62
    描述 Anti-Tim3 Antibody, clone 2E2
    Alternate Names
    • TIM-3
    • Hepatitis A virus cellular receptor 2 homolog
    • T-cell immunoglobulin and mucin domain-containing protein 3
    • T-cell membrane protein 3
    • TIMD-3
    背景信息 As a member of the T cell immunoglobulin and mucin domain (TIM) family, Tim-3 is reported to promote or terminate Th1 immunity and is thought to influence a range of inflammatory conditions. It is constitutively expressed in a subset of murine IFNgamma-secreting Th1 cells, but not Th2 cells, in both human and mice. Additionally, Tim-3 is expressed dendritic cells, and by a subset of CD4+ cells where its levels of expression increase upon anti-CD3/28 stimulation. This molecule is also highly expressed in in vitro polarized Th1 cells, and at lower levels in Th17 cells. It is known to synergize with Toll-like receptors and is thought to regulate Th1 and Th17 cytokine secretion.
    产品信息
    格式 Purified
    控制
    • Human thymus tissue lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Tim3 Antibody, clone 2E2 detects level of Tim3 & has been published & validated for use in WB, FC.
    主要应用
    • Flow Cytometry
    • Western Blotting
    应用说明 Flow Cytometry Analysis: A 1:1,000 dilution of this antibody detected Tim3 in human monocyte derived dendritic cells.
    生物信息
    免疫原品种 Recombinant protein corresponding to human Tim3.
    克隆 2E2
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_116171
    Entrez基因汇总 CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
    基因符号
    • TIMD3
    • HAVCR2
    • TIM3
    纯化方法 Protein G purified
    UniProt编号
    • Q8TDQ0
    UniProt汇总 FUNCTION: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.

    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    产品使用声明
    质量保证 Evaluated by Western Blot in human thymus tissue lysate.

    Western Blot Analysis: A 1:2,000 dilution of this antibody detected Tim3 in human thymus tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MABF62,Anti-Tim3 Antibody, clone 2E2

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