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品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-618 品牌系列 Upstate
商名 - Upstate
描述 Anti-SF-1 Antibody 背景信息 Steroidogenic factor-1 (SF-1) regulates multiple genes involved in the adrenal and gonadal development and in the biosynthesis of a variety of hormones, including adrenal and gonadal steroids, anti-Mullerian hormone (AMH), and gonadotropins. SF-1 belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors. In the adult ovary, SF-1 localizes to theca/interstitial cells. 产品信息 格式 Purified 控制 - Y1 cell lysate
演示 Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative. 应用 应用 Anti-SF-1 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of SF-1 & has been validated in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 DNA binding domain of SF-1 from mouse, produced in E. coli as a GST fusion protein and partially purified via GST-agarose column chromatography 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes SF-1. 同种型 IgG 品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_004959
Entrez基因汇总 The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. 基因符号 - OTTHUMP00000042846
- NR5A1
- FTZ1
- FTZF1
- AD4BP
- SF-1
- STF-1
- OTTHUMP00000042845
- SF1
- ELP
- OTTHUMP00000042847
纯化方法 Protein A purfied UniProt编号 - Q13285
UniProt汇总 FUNCTION: SwissProt: Q13285 # Transcriptional activator. Seems to be essential for sexual differentiation and sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. 5'- YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1/FTZF1. The SFPQ-NONO-NR5A1/SF-1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3.
SIZE: 461 amino acids; 51636 Da
SUBUNIT: Binds DNA as a monomer. Interacts with NR0B2 (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1/SF-1. Interacts with NCOA2.
SUBCELLULAR LOCATION: Nucleus.
PTM: Acetylation stimulates the transcriptional activity.
DISEASE: SwissProt: Q13285 # Defects in NR5A1 are a cause of XY sex reversal with adrenal failure [MIM:184757]. This disease is characterized by normal female external genitalia and retention of the uterus. & Defects in NR5A1 are a cause of adrenocortical insufficiency without ovarian defect [MIM:184757]. The disease is characterized by severe 'slackness,' muscular hypotonia. There is decreased sodium, increased potassium and elevated ACTH.
SIMILARITY: SwissProt: Q13285 ## Belongs to the nuclear hormone receptor family. NR5 subfamily. & Contains 1 nuclear receptor DNA-binding domain.产品使用声明 质量保证 Routinely evaluated by immunoblot on RIPA lysates from Y1 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 200 µg
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