merck millipore,默克密理博,251400,D609, Potassium Salt - CAS 83373-60-8

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merck millipore,默克密理博,251400,D609, Potassium Salt - CAS 83373-60-8 - Calbiochem
产品名称：D609, Potassium Salt - CAS 83373-60-8 - Calbiochem
产品型号：251400
Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki = 5-10 µM).

merck millipore,默克密理博,251400,D609, Potassium Salt - CAS 83373-60-8 - Calbiochem

产品介绍

merck millipore,默克密理博,251400,D609, Potassium Salt - CAS 83373-60-8 - Calbiochem

重要规格表

经验配方	CAS号
C₁₁H₁₅OS₂ · K	83373-60-8

描述
概述	Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (K_i = 5-10 µM). Does not inhibit phosphatidylinositol-specific phospholipase C, phospholipase A, or phospholipase D. Also reported to inhibit LPS-stimulated ERK activation via its inhibitory effect on PLC. Inhibits angiogenesis by preventing the synthesis of basement membrane.
产品目录编号	251400
品牌系列	Calbiochem®
同义词	Tricyclodecan-9-yl-xanthogenate, K

参考
参考	Monick, M.M., et al. 1999. J. Immunol. 162, 3005. Lozanski, G., et al. 1997. Biochem. J. 328, 271. Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147. Doppler, C., et al. 1992. AIDS Res. Human Retroviruses 8, 245. Schutze, S., et al. 1992. Cell 71, 765. Sauer, G., et al. 1990. Cancer Lett. 53, 97. Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun. 162, 198. Amtmann, E., et al. 1987. Biochem. Pharmacol. 36, 1545. Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 3263.

参考

Monick, M.M., et al. 1999. J. Immunol. 162, 3005.
Lozanski, G., et al. 1997. Biochem. J. 328, 271.
Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
Doppler, C., et al. 1992. AIDS Res. Human Retroviruses 8, 245.
Schutze, S., et al. 1992. Cell 71, 765.
Sauer, G., et al. 1990. Cancer Lett. 53, 97.
Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun. 162, 198.
Amtmann, E., et al. 1987. Biochem. Pharmacol. 36, 1545.
Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 3263.

产品信息
CAS号	83373-60-8
具有ATP竞争性	N
形式	Off-white powder
Hill配方	C₁₁H₁₅OS₂ · K
化学配方	C₁₁H₁₅OS₂ · K
Molar Mass	266.5
吸湿	Hygroscopic
可逆	N
结构配方图像

生物信息
主靶	pc-specificphopholipase c
主靶K_i	5-10 µM against phosphatidylcholine (PC)-specific phospholipase C
纯度	≥98% by HPLC

理化信息
细胞可渗透	N
溶解度	DMSO or H₂O

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Material is very labile once in solution (1.5 day half-life in tissue culture medium).