merck millipore,默克密理愽
  • merck millipore,默克密理博,07-1526,Anti-phospho-BRD2 Antibody (Ser37)

  • merck millipore,默克密理博,07-1526,Anti-phospho-BRD2 Antibody (Ser37)

    产品名称：Anti-phospho-BRD2 Antibody (Ser37)
    产品型号：07-1526
    Use Anti-phospho-BRD2 (Ser37) Antibody (Rabbit Polyclonal Antibody) validated in WB to detect phospho-BRD2 (Ser37) also known as Bromodomain-containing protein 2.

    merck millipore,默克密理博,07-1526,Anti-phospho-BRD2 Antibody (Ser37)

  • 产品介绍
  • merck millipore,默克密理博,07-1526,Anti-phospho-BRD2 Antibody (Ser37)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Xn, H, M, Mk, R, B, PoWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-1526
    描述 Anti-phospho-BRD2 Antibody (Ser37)
    Alternate Names
    • Really interesting new gene 3 protein
    • Bromodomain-containing protein 2
    • O27.1.1
    背景信息 Bromodomain-containing protein 2 (BRD2) is a member of the BET subfamily of bromodomain proteins. These proteins contain two tandem N-terminal bromodomains and a single C-terminal extra-terminal domain. Studies have shown BRD2 to be associated with several regulators of transcription (eg. TFIID and Swi/Snf complexes) in addition to its involvement in guiding cell cycle gene expression through its binding to multiple E2F. BRD2 is hypothesized to function in mammalian development by regulating chromatin structure and transcription. Consistent with this hypothesis, studies have shown BRD2 to bind histone H4 via acetylated Lys12. BRD2 mutants have been associated with increased susceptibility to juvenile myoclonic epilepsy.
    产品信息
    格式 Affinity Purified
    控制
    • PMA untreated and treated NIH/3T3 cell lysates
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-phospho-BRD2 (Ser37) Antibody (Rabbit Polyclonal Antibody) validated in WB to detect phospho-BRD2 (Ser37) also known as Bromodomain-containing protein 2.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Linear peptide corresponding to human BRD2 phosphorylated at Ser37.
    表位 Phosphorylated Ser37
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes BRD2 phosphorylated at Ser37.
    品种反应性 XenopusHumanMouseMonkeyRatBovinePig
    Species Reactivity Note Demonstrated to react with Human, Mouse, and Monkey. Predicted to react with Rat, Bovine, Porcine, Xenopus, and Zebra Fish based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_005095
    Entrez基因汇总 This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010].
    基因符号
    • RING3
    • BRD2
    修改
    • Phosphorylation
    纯化方法 Affinity purified
    UniProt编号
    • P25440
    UniProt汇总 FUNCTION: May play a role in spermatogenesis or folliculogenesis (By similarity).

    SUBUNIT STRUCTURE: Homodimer. Interacts with E2F1 and with histone H4 acetylated at 'Lys-13'.

    SUBCELLULAR LOCATION: Nucleus (By similarity).

    DOMAIN: One bromodomain is sufficient for a partial interaction with histone H4 acetylated at 'Lys-13'.

    SEQUENCE SIMILARITIES: Contains 2 bromo domains.

    Contains 1 ET domain.

    SEQUENCE CAUTION: The sequence AAA68890.1 differs from that shown. Reason: Erroneous initiation.
    产品使用声明
    质量保证 Evaluated by Western Blot in PMA untreated and treated NIH/3T3 cell lysates.

    Western Blot Analysis: 2 µg/mL of this antibody detected BRD2 on 10 µg of PMA untreated and treated NIH/3T3 cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,07-1526,Anti-phospho-BRD2 Antibody (Ser37)

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