merck millipore,默克密理愽
  • merck millipore,默克密理博,07-896,Anti-phospho-Rac1/cdc42 (Ser71) Antibody

  • merck millipore,默克密理博,07-896,Anti-phospho-Rac1/cdc42 (Ser71) Antibody

    产品名称：Anti-phospho-Rac1/cdc42 (Ser71) Antibody
    产品型号：07-896
    Anti-phospho-Rac1/cdc42 (Ser71) Antibody detects level of phospho-Rac1/cdc42 (Ser71) & has been published & validated for use in WB.

    merck millipore,默克密理博,07-896,Anti-phospho-Rac1/cdc42 (Ser71) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-896,Anti-phospho-Rac1/cdc42 (Ser71) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-896
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-Rac1/cdc42 (Ser71) Antibody
    产品信息
    格式 Affinity Purified
    应用
    应用 Anti-phospho-Rac1/cdc42 (Ser71) Antibody detects level of phospho-Rac1/cdc42 (Ser71) & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-Rac1/cdc42 (Ser71).
    宿主 Rabbit
    特异性 Recognizes phosphorylated Rac1/cdc42 (Ser71)
    同种型 IgG
    品种反应性 Human
    Species Reactivity Note Predicted to cross react with mouse based on sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_198829.1
    • NM_006908.3
    • NM_018890.2
    Entrez基因汇总 The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
    基因符号
    • MIG5
    • RAC1
    • ORFNames=MIG5
    • TC-25
    • p21-Rac1
    • MGC111543
    • PAK1
    修改
    • Phosphorylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P63000
    UniProt汇总 FUNCTION: SwissProt: P63000 # Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP- dependent manner, suggesting that the insertion does not completely abolish effector interaction.
    SIZE: 192 amino acids; 21450 Da
    SUBUNIT: Interacts with the GEF proteins PREX1, RASGRF2, DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and GTP, and therefore activate it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ), which plays a central role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with PLXNB1. Part of a complex with MAP2K3, MAP3K3, CCM2 and DEF6. Interacts with BAIAP2, CYFIP1/SRA-1 and DEF6. Interacts with Y.pseudotuberculosis YPKA and PLCB2.
    SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Melanosome. Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the C- terminal cysteine (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    TISSUE SPECIFICITY: Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. The expression of isoform B is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their respective adjacent tissues.
    DOMAIN: SwissProt: P63000 The effector region mediates interaction with DEF6.
    SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-896,Anti-phospho-Rac1/cdc42 (Ser71) Antibody

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