merck millipore,默克密理博,MABF577,Anti-CD4 Antibody (mouse), APC-Cy7, clone RM4-5

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M	FC, IHC	R	APC-Cy7	Monoclonal Antibody

描述
产品目录编号	MABF577
描述	Anti-CD4 Antibody (mouse), APC-Cy7, clone RM4-5
Alternate Names	CD4 T-cell surface glycoprotein CD4 T-cell differentiation antigen L3T4 T-cell surface antigen T4/Leu-3
背景信息	The RM4-5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta2-domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The RM4-5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the RM4-5 antibody and an alternative antibody, Anti-Mouse CD4 clone GK1.5, will “compete” for binding, i.e. RM4-5 antibody is able to block GK1.5 antibody binding to cells. In contrast, RM4-5 antibody does not block the binding of Anti-Mouse CD4 clone RM4-4 to cells.

产品信息
格式	APC-Cy7
演示	Purified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.

应用
应用	This rat monoclonal antibody Anti-CD4 (mouse), APC-Cy7, clone RM4-5 validated for use in IP, IHC, Immunofluorescence & Flow Cytometry for the detection of CD4.
主要应用	Flow Cytometry Immunohistochemistry

生物信息
免疫原品种	Immunogen information for this antibody is proprietary information.
克隆	RM4-5
浓缩	0.2 mg/mL
宿主	Rat
同种型	IgG2aκ
品种反应性	Mouse
抗体类型	Monoclonal Antibody
基因符号	Cd4
纯化方法	Size Exclusion Chromatography
UniProt编号	P06332

产品使用声明
质量保证	The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. Flow Cytometry Analysis: 0.25 μg of this antibody detected CD4 in one million C57Bl/6 splenocytes.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

包装信息
数量	25 µg

merck millipore,默克密理博,MABF577,Anti-CD4 Antibody (mouse), APC-Cy7, clone RM4-5

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