merck millipore,默克密理愽
  • merck millipore,默克密理博,MABF267,Anti-Cochlin Antibody/COCH, clone 9A10D2

  • merck millipore,默克密理博,MABF267,Anti-Cochlin Antibody/COCH, clone 9A10D2

    产品名称：Anti-Cochlin Antibody/COCH, clone 9A10D2
    产品型号：MABF267
    This Anti-Cochlin Antibody/COCH, clone 9A10D2 is validated for use in Western Blotting and Immunohistochemistry for the detection of Cochlin/COCH.

    merck millipore,默克密理博,MABF267,Anti-Cochlin Antibody/COCH, clone 9A10D2

  • 产品介绍
  • merck millipore,默克密理博,MABF267,Anti-Cochlin Antibody/COCH, clone 9A10D2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HIHC, WBRPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABF267
    描述 Anti-Cochlin Antibody/COCH, clone 9A10D2
    Alternate Names
    • COCH-5B2
    • Cochlin
    背景信息 The protein Cochlin/COCH is important in the development of the cochlea and vestibule in mammals as well as other functions. Cochlin/COCH is an extracellular matrix protein that plays a role in cell shape, positioning and motility. Recent research shows that it is also important in our innate immune response to bacteria and pathogens. Upon bacterial infection, a fragment of Cochlin/COCH is released from the conduits of B cell follicles in the spleen and this triggers protective cytokines in the periphery. Cochlin/COCH is expressed in epithelial tissues in various tissues, particularly in follicular cells and network of conduits in the spleen and lymph nodes. Cochlin/COCH also is a target for BMP4 mediation in embryonic stem cells (ESCs) where it facilitates self-renewal. The protein also appears to suppress neural differentiation of ESCs and suggests that Cochlin/COCH protein is important in ES cell fate determination. Mutations in the Cochlin/COCH gene are responsible for human DFNA9 syndrome, a disorder characterized by neurodegeneration of the inner ear that leads to hearing loss and vestibular impairments.
    产品信息
    格式 Purified
    演示 Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-Cochlin Antibody/COCH, clone 9A10D2 is validated for use in Western Blotting and Immunohistochemistry for the detection of Cochlin/COCH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Cochlin/COCH in 10 µg of human lymph node tissue lysate.
    Western Blotting Analysis: A representative lot detected Cochlin/COCH in spleen and lymph node from WT and COCH knockout mice (Py, B.F., et al. (2013). Immunity. 38:1063-1072).
    Western Blotting Analysis: A representative lot detected Cochlin/COCH in protein cleaved into p18 and p8 products. (Py, B.F., et al. (2013). Immunity. 38:1063-1072).
    Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Cochlin/COCH in mouse spleen tissue.
    Immunohistochemistry Analysis: A representative lot detected Cochlin/COCH in spleen and lymphnode from WT and Coch knockout mice (Py, B.F., et al. (2013). Immunity. 38:1063-1072).
    生物信息
    免疫原品种 Recombinant protein corresponding to human Cochlin/COCH.
    克隆 9A10D2
    浓缩 Please refer to lot specific datasheet.
    宿主 Rat
    同种型 IgG2aκ
    品种反应性 MouseHuman
    Species Reactivity Note Human, Mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001128530
    基因符号
    • COCH5B2
    • COCH
    纯化方法 Protein G purified
    UniProt编号
    • O43405
    产品使用声明
    质量保证 Evaluated by Western Blotting in mouse spleen tissue lysate.

    Western Blotting Analysis: 1.0 µg/mL of this antibody detected Cochlin/COCH in 10 µg of mouse spleen tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABF267,Anti-Cochlin Antibody/COCH, clone 9A10D2

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