merck millipore,默克密理愽
  • merck millipore,默克密理博,616379,Toxin A, Clostridium difficile - Calbiochem

  • merck millipore,默克密理博,616379,Toxin A, Clostridium difficile - Calbiochem

    产品名称：Toxin A, Clostridium difficile - Calbiochem
    产品型号：616379
    A high molecular weight glucosyltransferase that inhibits small GTPases, such as Rho, Rac, and Cdc42, by glucosylation of a threonine residue.

    merck millipore,默克密理博,616379,Toxin A, Clostridium difficile - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,616379,Toxin A, Clostridium difficile - Calbiochem

    重要规格表
    描述
    概述 A high molecular weight glucosyltransferase that inhibits small GTPases, such as Rho, Rac, and Cdc42, by glucosylation of a threonine residue. This results in the shutdown of signal transduction cascades, leading to depolymerization of the cytoskeleton, gene transcription of a number of stress-activated protein kinases (SAPKs), and a decrease in the synthesis of phosphatidylinositol 4,5-bisphosphate. Unlike Exoenzyme C3 (Cat. No. 341208), this toxin does not require assistance to permeabilize cells.
    产品目录编号 616379
    品牌系列 Calbiochem®
    同义词 Enterotoxin
    参考
    参考 Mackay, D.J. and Hall, A. 1998. J. Biol. Chem. 273, 20685.
    Mahida, Y.R., et al. 1996. Gut 38, 337.
    Wilkins, T.D. and Lyerly, D.M. 1996. Trends Microbiol. 4, 49.
    产品信息
    具有ATP竞争性 N
    形式 Solid
    配方 Lyophilized from 50 mM Tris, 50 mM NaCl, 0.1% trehalose, pH 7.5.
    Molar Mass 300000
    可逆 N
    生物信息
    生物活性 Binds to fresh rabbit red blood cells in a hemagglutination assay. Cytotoxic as determined by a cell rounding assay using human foreskin cells
    主靶 Small GTPases, such as Rho, Rac, and Cdc42
    纯度 Single band by SDS-PAGE
    理化信息
    细胞可渗透 N
    溶解度 Sterile dH₂O
    GHS安全信息
    RTECS KA8080200
    安全信息
    R相 R: 26/27/28-36/37/38

    Very toxic by inhalation, in contact with skin and if swallowed.
    Irritating to eyes, respiratory system and skin.
    S相 S: 26-36/37/39-45

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing, gloves and eye/face protection.
    In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Highly Toxic
    有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
    储存 +2°C to +8°C
    无需冷冻 No
    特殊指南 Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 week at 4°C. Toxin A activity was found to decrease to 1/10 after one week storage at 4°C following reconstitution.

    merck millipore,默克密理博,616379,Toxin A, Clostridium difficile - Calbiochem

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