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描述 产品目录编号 ECM460 品牌系列 Chemicon®
商名 - Chemicon
描述 αVβ3/PECAM Investigator Kit 概述 Chemicon Investigator Kits for Integrin Research are a cost-effective source of reagents for all investigators involved with this rapidly expanding field of study. The alphaVbeta3 / PECAM Integrin Investigator Kit is designed for research focused on the presence of the human alphaVbeta3 integrin subunit on PECAM-1 [CD31] expressing cells. The alphaVbeta3 / PECAM Integrin Investigator Kit contains 100 mg each of Cy5-conjugated mouse anti-integrin alphaVbeta3 and Fluorescein-conjugated mouse anti-PECAM-1 [CD31] monoclonal antibodies.
Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.
The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator. The combination of Cy5 and Fluorescein labels permits simultaneous labeling of Integrin alphaVbeta3 and PECAM in flow cytometry or immunofluorescence.
This kit and reagents is not intended for use in a diagnostic or clinical setting.产品信息 部件 - PECAM [CD31] Fluorescein-conjugated Mouse Monoclonal Antibody (Part No. MAB2148F-100)- 1 tube, 100 μg.
- Integrin alphaVbeta3 Cy5-conjugated Mouse Monoclonal Antibody (Part No. MAB1976S-100)- 1 tube, 100 μg.
演示 100 μg each of monoclonals to alphaVbeta3 and PECAM, labeled with CY5 and FITC, respectively. 应用 主要应用 - Flow Cytometry
- ELISA
- Immunocytochemistry
- Immunohistochemistry
生物信息 品种反应性 Human Entrez基因编号 - NM_002210.2
Entrez基因汇总 ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. 基因符号 - MSK8
- ITGAV
- CD51
- DKFZp686A08142
- VNRA
UniProt编号 - P06756
UniProt汇总 FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 1048 amino acids; 116038 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store antibodies at 2-8°C. Protect from light.
Important Note: Due to the small volumes contained within the kit, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid entrapped in the container's cap during shipment.包装信息 数量 1 kit
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