merck millipore,默克密理愽
  • merck millipore,默克密理博,475954,MRN-ATM Pathway Inhibitor, Mirin - CAS 299953-00-7 - Calbiochem

  • merck millipore,默克密理博,475954,MRN-ATM Pathway Inhibitor, Mirin - CAS 299953-00-7 - Calbiochem

    产品名称：MRN-ATM Pathway Inhibitor, Mirin - CAS 299953-00-7 - Calbiochem
    产品型号：475954
    The MRN-ATM Pathway Inhibitor, Mirin, also referenced under CAS 299953-00-7, controls the biological activity of Mre11, component of the MRN (Mre11-Rad50-Nbs1) complex. This small molecule/inhibitor i More>>

    merck millipore,默克密理博,475954,MRN-ATM Pathway Inhibitor, Mirin - CAS 299953-00-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,475954,MRN-ATM Pathway Inhibitor, Mirin - CAS 299953-00-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₀H₈N₂O₂S299953-00-7
    描述
    概述 A cell-permeable pyrimidinone compound that inhibits the exonuclease activity of Mre11, component of the MRN (Mre11-Rad50-Nbs1) complex, and prevents MRN-mediated activation of dimeric ATM (IC50 = 12 µM) in cell-free p53 Ser15 phosphorylation assays, while exhibiting little effect against MRN-independent ATM activation in the presence of high DSBs (DNA double strain breaks) or the activity of activated monomeric ATM. Mirin is shown to cause an increase of G2 population in exponentially growing TOSA4 cultures (~1.6-fold at 50 µM) and dramatically increase mitotic cell polulation (~10-fold at 25 µM) after irradiation of G2 phase U2OS cultures by preventing IR-induced G2/M checkpoint. Mirin exhibits no inhibitory activity against Rad50-associated adenylate kinase or Exonulease III.
    产品目录编号 475954
    品牌系列 Calbiochem®
    同义词 (Z)-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one, Mirin
    参考
    参考 Garner, K.M., et al. 2009. Nature Chem. Biol. 5, 129.
    Peterson, S., et al. 2009. Nature Chem. Biol. 5, 130.
    Dupre, A., et al. 2008. Nature Chem. Biol. 4, 119.
    产品信息
    CAS号 299953-00-7
    形式 Reddish orange powder
    Hill配方 C₁₀H₈N₂O₂S
    化学配方 C₁₀H₈N₂O₂S
    Molar Mass 220.3
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,475954,MRN-ATM Pathway Inhibitor, Mirin - CAS 299953-00-7 - Calbiochem

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