merck millipore,默克密理愽
  • merck millipore,默克密理博,402087,7BIO - CAS 916440-85-2 - Calbiochem

  • merck millipore,默克密理博,402087,7BIO - CAS 916440-85-2 - Calbiochem

    产品名称：7BIO - CAS 916440-85-2 - Calbiochem
    产品型号：402087
    A cell-permeable 6-BIO structural isomer that acts as an ATP-competitive inhibitor of Flt3 and a caspase-independent, non-apoptotic cell death inducer.

    merck millipore,默克密理博,402087,7BIO - CAS 916440-85-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,402087,7BIO - CAS 916440-85-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₆H₁₀BrN₃O₂916440-85-2
    描述
    概述 A cell-permeable 6-BIO (Cat. Nos. 361550 and 361552) structural isomer that acts as an ATP-competitive inhibitor of Flt3 (IC50 = 340 nM) and a caspase-independent, non-apoptotic cell death inducer (IC50 of cell survival ranges from 6.0 µM to 22.0 µM). Inhibition study against 75 other kinases reveals 10- to 80-fold selectivities over a group of 14 kinases, including TSF1, Aurora-A, and Aurora-B (IC50 = 3.3, 4.7, and 6.6 µM, respectively), up to 280-fold selectivities over a second group of 15 kinases, and little activity against the remaining 46 kinases of the panel (IC50 >100 µM).
    产品目录编号 402087
    品牌系列 Calbiochem®
    同义词 (2ʹZ,3ʹE)-7-Bromoindirubin-3ʹ-oxime, Indirubin-3ʹ-monoxime, 7-Bromo, 7-Bromoindirubin-oxime
    参考
    参考 Zahler, S., et al. 2007. Chem. Biol. 14, 1207.
    Myrianthopoulos, V., et al. 2007. J. Med. Chem. 50, 4027.
    Ferandin, Y., et al. 2006. J. Med. Chem. 49, 4638.
    Ribas, J., et al. 2006. Oncogene 25, 6304.
    产品信息
    CAS号 916440-85-2
    形式 Deep black-red solid
    Hill配方 C₁₆H₁₀BrN₃O₂
    化学配方 C₁₆H₁₀BrN₃O₂
    Molar Mass 356.2
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Blue Ice Only
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,402087,7BIO - CAS 916440-85-2 - Calbiochem

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