merck millipore,默克密理博,04-1113,Anti-FADD (NT) Antibody, clone EP887Y, rabbit monoclonal

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merck millipore,默克密理博,04-1113,Anti-FADD (NT) Antibody, clone EP887Y, rabbit monoclonal
产品名称：Anti-FADD (NT) Antibody, clone EP887Y, rabbit monoclonal
产品型号：04-1113
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-FADD (N-terminal) Antibody, clone EP887Y, More>>

merck millipore,默克密理博,04-1113,Anti-FADD (NT) Antibody, clone EP887Y, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-1113,Anti-FADD (NT) Antibody, clone EP887Y, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M, H	WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	04-1113
描述	Anti-FADD (NT) Antibody, clone EP887Y, rabbit monoclonal
Alternate Names	mediator of receptor-induced toxicity FAS-associated death domain protein FAS-associating death domain-containing protein Fas (TNFRSF6)-associated via death domain Fas-associated via death domain Fas-associating protein with death domain Mediator of receptor induced toxicity growth-inhibiting gene 3 protein
背景信息	FADD was originally isolated as a protein that bound to the cytoplasmic domain of Fas in the yeast two-hybrid system. Sequence analysis revealed a region homologous to the death domain of Fas and TNFR-1. Subsequent biochemical studies have shown that FADD associates with FAS through interaction of the death domains. When over expressed in several cell lines, FADD induces apoptosis, which can be blocked by CrmA, an inhibitor of inerleukin-1-beta-converting enzyme. This evidence suggests that FADD plays a role in Fas-mediated apoptosis.

产品信息
格式	Unpurified
控制	Jurkat lysates
演示	Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.18 M NaCl containing 40% Glycerol, 0.25% sodium azide, 0.25 mM EDTA, 25 mM Citric Acid, and 0.5% BSA.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-FADD (N-terminal) Antibody, clone EP887Y, Rabbit is validated for use in IH(P), WB for the detection of FADD (N-terminal).
主要应用	Western Blotting
应用说明	Immunohistochemistry Analysis: 1:250 dilution from a previous lot detected FADD in human lung tissue.

生物信息
免疫原品种	Synthetic peptide corresponding to residues near the N-terminus of human FADD.
表位	N-terminus
克隆	EP887Y
宿主	Rabbit
特异性	This antibody recognizes FADD.
同种型	IgG
品种反应性	MouseHuman
Species Reactivity Note	Human, Mouse
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_034305.1
基因符号	MORT1 GIG3 MGC8528
纯化方法	Unpurified
UniProt编号	Q13158
UniProt汇总	FUNCTION: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. SUBUNIT STRUCTURE: Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD. TISSUE SPECIFICITY: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes. DOMAIN: Contains a death domain involved in the binding of the corresponding domain within Fas receptor. PTM: Phosphorylated. SEQUENCE SIMILARITY: Contains 1 death domain. Contains 1 DED (death effector) domain.

产品使用声明
质量保证	Evaluated by Western Blot on Jurkat cell lysates. Western Blotting Analysis: 1:500 dilution of this antibody was used to detect FADD in Jurkat cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.