merck millipore,默克密理博,MABF22,Anti-IL-1 Beta (CT) Antibody, clone EP408Y, rabbit monoclonal

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merck millipore,默克密理博,MABF22,Anti-IL-1 Beta (CT) Antibody, clone EP408Y, rabbit monoclonal
产品名称：Anti-IL-1 Beta (CT) Antibody, clone EP408Y, rabbit monoclonal
产品型号：MABF22
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-IL-1 Beta (C-term) Antibody, clone EP408Y, More>>

merck millipore,默克密理博,MABF22,Anti-IL-1 Beta (CT) Antibody, clone EP408Y, rabbit monoclonal

产品介绍

merck millipore,默克密理博,MABF22,Anti-IL-1 Beta (CT) Antibody, clone EP408Y, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABF22
描述	Anti-IL-1 Beta (CT) Antibody, clone EP408Y, rabbit monoclonal
Alternate Names	Catabolin interleukin 1, beta catabolin pro-interleukin-1-beta preinterleukin 1 beta interleukin-1 beta
背景信息	Interleukin 1 beta (IL-1β) is a proinflammatory cytokine belonging to IL1 family. There are two known forms of IL1, IL1 alpha (predominant form in mice) and IL1 beta (predominant form in humans). IL1 beta and alpha are both synthesized as precursor. The IL1 beta precursor form is not biologically active, while IL1 alpha is. Expressed mainly by stimulated macrophages and monocytes, IL1 beta precursor is cleaved by Caspase 1/ICE and other proteases (2-3). Activated IL1 alpha remains mostly in the cytosol, activated IL1 beta is widely secreted. IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohn’s disease which makes IL1 beta an important target for this disease (4).

产品信息
格式	Unpurified
控制	Recombinant protein, human IL-1 beta
演示	Rabbit monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-IL-1 Beta (C-term) Antibody, clone EP408Y, Rabbit is validated for use in WB for the detection of IL-1 Beta (C-term).
主要应用	Western Blotting

生物信息
免疫原品种	Synthetic peptide corresponding to human IL-1 Beta near the C-terminus.
表位	C-terminus
克隆	EP408Y
宿主	Rabbit
特异性	This antibody recognizes IL-1 Beta near the C-terminus.
同种型	IgG
品种反应性	Human
Species Reactivity Note	Proven to react with human.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_000567.1
Entrez基因汇总	The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
基因符号	IL1-BETA IL1F2 IL-1 beta IL-1B IL-1 OTTHUMP00000203693 OTTHUMP00000203695 OTTHUMP00000203694
纯化方法	Unpurified
UniProt编号	P01584
UniProt汇总	FUNCTION: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. SUBUNIT STRUCTURE: Monomer. SUBCELLULAR LOCATION: Secreted. Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. DOMAIN: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. SEQUENCE SIMILARITIES: Belongs to the IL-1 family.

产品使用声明
质量保证	Evaluated by Western Blot using recombinant human IL-1 beta. Western Blot Analysis: A 1:5,000 dilution of this antibody detected recombinant human IL-1 Beta. Note: Approximately 0.05 µg/lane [0.5 µg/200 µL] of recombinant protein was loaded on the membrane.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.