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经验配方 C₂₈H₂₃N₅O₅Ru 描述 概述 The racemic mixture of a pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a ATP-binding site-targeting, reversible, and highly potent inhibitor of PIM-1 (IC50 = 0.5 and 3 nM for the (S)- and (R)-enantiomer, respectively) with ∼10-fold selectivity over GSK-3α (IC50 = 15 and 20 nM for the (S)- and (R)-enantiomer, respectively). 产品目录编号 526521 品牌系列 Calbiochem®
参考 参考 Bergman, H. and Meggers, E., 2006. Org. Lett. 8, 5465. 产品信息 具有ATP竞争性 N 声明 Sold for research purposes only, pursuant to an agreement with University of Pennsylvania. 形式 Purple solid Hill配方 C₂₈H₂₃N₅O₅Ru 化学配方 C₂₈H₂₃N₅O₅Ru Molar Mass 610.6 可逆 N 结构配方图像 生物信息 主靶 PIM1 主靶IC50 0.5 and 3 nM for the (S)- and (R)-enantiomer, of PIM-1, respectively 纯度 ≥95% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO 储存和货运信息 货运代码 Blue Ice Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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