merck millipore,默克密理愽
  • merck millipore,默克密理博,MABF106,Anti-Viperin Antibody, clone MaP.VIP

  • merck millipore,默克密理博,MABF106,Anti-Viperin Antibody, clone MaP.VIP

    产品名称：Anti-Viperin Antibody, clone MaP.VIP
    产品型号：MABF106
    Anti-Viperin Antibody, clone MaP.VIP detects level of Viperin & has been published & validated for use in WB, IH, FC, IP & IC.

    merck millipore,默克密理博,MABF106,Anti-Viperin Antibody, clone MaP.VIP

  • 产品介绍
  • merck millipore,默克密理博,MABF106,Anti-Viperin Antibody, clone MaP.VIP

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, M, HICC, WB, IHC, FCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABF106
    描述 Anti-Viperin Antibody, clone MaP.VIP
    Alternate Names
    • Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
    • Radical S-adenosyl methionine domain-containing protein 2
    • Cytomegalovirus-induced gene 5 protein
    • Viperin
    背景信息 Virus inhibitory protein endoplasmic reticulum-associated interferon-inducible (Viperin) belongs to the RSAD2 family and is highly inducible by both type I and type II interferons, but little or no induction is observed in moncytic cell lines. Studies suggest that viperin is involved in host antiviral response, as viperin induction is observed from viral infections. Research also reveals that viperin inhibits influenza replication by disrupting its release from the plasmic membrane through the altering of plasma membrane fluidity by affecting formation of lipid rafts. Lipid rafts are known detergent-resistant microdomian sites for influenza budding.
    产品信息
    格式 Purified
    控制
    • Mouse macrophage stimulated with IFN gamma and LPS
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Viperin Antibody, clone MaP.VIP detects level of Viperin & has been published & validated for use in WB, IH, FC, IP & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    • Immunohistochemistry
    • Flow Cytometry
    应用说明 Immunohistochemistry Analysis: A 1:500-1:1,000 dilution from a representative lot detected Viperin in human colon and rat liver tissues.

    Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in HepG2 cell lysate (Hinson, E., et al. (2008). JBC. 284(7):4705–4712).

    Flow Cytometry Analysis: A representative lot was used by an independent laboratory in mouse liver, spleen, lung, and lymph node cells (Hinson, E., et al. (2010). J. Immunol. 184:5723-5731).

    Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in mouse spleen cells (Hinson, E., et al. (2010). J. Immunol. 184:5723-5731).
    生物信息
    免疫原品种 Recombinant protein corresponding to human Viperin.
    克隆 MaP.VIP
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2aκ
    品种反应性 RatMouseHuman
    Species Reactivity Note Demonstrated to react with Human, Mouse and Rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_542388
    基因符号
    • CIG5
    • RSAD2
    纯化方法 Protein G Purified
    UniProt编号
    • Q8WXG1
    UniProt汇总 FUNCTION: Involved in antiviral defense. May impair virus budding by disrupting lipid rafts at the plasma membrane, a feature which is essential for the budding process of many viruses. Acts through binding with and inactivating FPPS, an enzyme involved in synthesis of cholesterol, farnesylated and geranylated proteins, ubiquinones dolichol and heme. Plays a major role in the cell antiviral state induced by type I and type II interferon. Displays antiviral effect against HIV-1 virus, hepatitis C virus, human cytomegalovirus, and aphaviruses, but not vesiculovirus. COFACTOR: Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).

    SUBUNIT STRUCTURE: Interacts with FPPS.

    SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus. Note: Probably associates with the cytosolic side of the endoplasmic reticulum. Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi apparatus and to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B and pp28.

    INDUCTION: By interferon type I, type II and bacterial lipopolysaccharides (LPS). Little or no induction by IFNG/IFN-gamma is observed in monocytic cell lines. Induced by infection with human cytomegalovirus (HMCV), hepatitis C virus, yellow fever virus and Sendai virus, presumably through type I interferon pathway.

    MISCELLANEOUS: Up-regulated in atherosclerosis. Latent viruses like HCMV may be involved in atherogenesis by initiating local inflammation. This may induce up-regulation of antiviral gene RSAD2, which modulates lipids synthesis, and thus could play a role in abnormal lipid accumulation leading to atherosclerosis.

    SEQUENCE SIMILARITIES: Belongs to the RSAD2 family.
    产品使用声明
    质量保证 Evaluated by Western Blot in mouse macrophage stimulated with IFN gamma and LPS.

    Western Blot Analysis: 1 µg/mL of this antibody detected Viperin in 10 µg of mouse macrophage stimulated with IFN gamma and LPS.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABF106,Anti-Viperin Antibody, clone MaP.VIP

上一件merck millipore产品：merck millipore,默克密理博,2910,Whole Cell Extraction Kit
下一件merck millipore产品：merck millipore,默克密理博,MAB985,Anti-Echovirus 4 Antibody, clone 431-4H-6H-3B


相关产品

merck millipore,默克密理博,MABN518,Anti-Tafazzin Antibody, clone N173B/13 merck millipore,默克密理博,MABN518,Anti-Tafazzin Antibody, clone N173B/13

merck millipore,默克密理博,MABT62,Anti-Nectin-2/PVRL2 (CD112) Antibody, clone R2.525 merck millipore,默克密理博,MABT62,Anti-Nectin-2/PVRL2 (CD112) Antibody, clone R2.525

merck millipore,默克密理博,MAB4147,Anti-MRP1 Antibody, clone MRPm5 merck millipore,默克密理博,MAB4147,Anti-MRP1 Antibody, clone MRPm5

merck millipore,默克密理博,17-10156,LentiBrite™ α-actinin-GFP Lentiviral Biosensor merck millipore,默克密理博,17-10156,LentiBrite™ α-actinin-GFP Lentiviral Biosensor

merck millipore,默克密理博,2910,Whole Cell Extraction Kit merck millipore,默克密理博,2910,Whole Cell Extraction Kit

merck millipore,默克密理博,MAB985,Anti-Echovirus 4 Antibody, clone 431-4H-6H-3B merck millipore,默克密理博,MAB985,Anti-Echovirus 4 Antibody, clone 431-4H-6H-3B

merck millipore,默克密理博,56755,Sorbitol - CAS 50-70-4 - Calbiochem merck millipore,默克密理博,56755,Sorbitol - CAS 50-70-4 - Calbiochem

merck millipore,默克密理博,69240,S. cerevisiae Genomic DNA merck millipore,默克密理博,69240,S. cerevisiae Genomic DNA

merck millipore,默克密理博,204888,Complement C5, Human merck millipore,默克密理博,204888,Complement C5, Human

merck millipore,默克密理博,CB1041,Anti-RDX Mouse mAb (1E12) merck millipore,默克密理博,CB1041,Anti-RDX Mouse mAb (1E12)


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部