merck millipore,默克密理博,204888,Complement C5, Human

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Merck Millipore 默克密理愽

merck millipore,默克密理博,204888,Complement C5, Human
产品名称：Complement C5, Human
产品型号：204888

merck millipore,默克密理博,204888,Complement C5, Human

描述
概述	Native, human C5 complement component. Glycoprotein composed of two non-identical subunits of M.W. 120 kDa (α) and 75 kDa (β) linked by disulfide bonds. Present in normal human serum at 70 µg/ml. Activation of complement via either the classical or alternative pathway can result in the assembly of C5-cleaving enzymes (C5 convertases) on target surfaces. Both C5 convertases cleave the C5 α-chain at peptide bond 74 resulting in production of C5a (M.W. 11,200) and C5b fragments (M.W. 185,000). Released C5a peptide is one of the three complement-derived anaphylatoxins. C5b fragment combines with C6, C7, C8, and C9 to form lytic C5b-9 complement membrane attack complex (MAC).
产品目录编号	204888
品牌系列	Calbiochem®

参考
参考	Janatova, J. 1988. Methods Enzymol. 162, 579. Wetsel, R.A., et al. 1980. J. Immunol. Methods 35, 319.

生物信息
生物活性	≥100,000 C₅H₅0 units/mg; ≥60% of the C5 activity in normal human serum on a mg/mg basis
纯度	≥95% by SDS-PAGE
来源	Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
浓缩标签	Please refer to vial label for lot-specific concentration

理化信息
污染物	IgG, IgA, IgM, albumin, ceruloplasmin or functionally C3, C6, C7, C8, or C9: ≤trace amounts

储存和货运信息
货运代码	Dry Ice Only
毒性	Standard Handling
储存	≤ -70°C
避免冻结 / 解冻	Avoid freeze/thaw
无需冷冻	No
特殊指南	Following initial thaw, aliquot and freeze (-70°C).

merck millipore,默克密理博,204888,Complement C5, Human

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