merck millipore,默克密理博,MABE583,Anti-DDB1, clone EPR6088, Rabbit Monoclonal Antibody

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,MABE583,Anti-DDB1, clone EPR6088, Rabbit Monoclonal Antibody
产品名称：Anti-DDB1, clone EPR6088, Rabbit Monoclonal Antibody
产品型号：MABE583
This Anti-DDB1, clone EPR6088, Rabbit Monoclonal Antibody is validated for use in Western Blotting for the detection of DDB1.

merck millipore,默克密理博,MABE583,Anti-DDB1, clone EPR6088, Rabbit Monoclonal Antibody

产品介绍

merck millipore,默克密理博,MABE583,Anti-DDB1, clone EPR6088, Rabbit Monoclonal Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M, H	WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABE583
描述	Anti-DDB1, clone EPR6088, Rabbit Monoclonal Antibody
Alternate Names	XPCe DNA damage-binding protein 1 DDB p127 subunit DNA damage-binding protein a DDBa Damage-specific DNA-binding protein 1 HBV X-associated protein 1 XAP-1 UV-damaged DNA-binding factor UV-damaged DNA-binding protein 1 UV-DDB 1 XPE-binding factor XPE-BF Xeroderma pigmentosum group E-complementing protein
背景信息	DDB1, also known as DNA damage-binding protein 1, or DDB p127 subunit, or DNA damage-binding protein A (DDBa), Damage-specific DNA-binding protein 1, HBV X-associated protein 1 (XAP-1), UV-damaged DNA-binding factor, UV-damaged DNA-binding protein 1 (UV-DDB 1), XPE-binding factor (XPE-BF), or Xeroderma pigmentosum group E-complementing protein (XPCe), and encoded by the gene DDB1/XAP1, is a component of the UV-DDB complex that is required for the DNA repair of UV-damaged DNA. DDB1 also a component in the DCX(DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. Additionally DDB1, via the DCX complexes, allows for histones to get ubiquitinated and this may facilitate their removal from the nucleosome and promote subsequent DNA repair. DDB1 is localized to the cytoplasm and nucleus but primarily cytoplasmic except after UV irradiation, then the protein translocates to the nucleus and accumulates at sites of DNA damage. This protein serves as a popular UV treated marker.

产品信息
格式	Unpurified
演示	Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

应用
应用	This Anti-DDB1, clone EPR6088, Rabbit Monoclonal Antibody is validated for use in Western Blotting for the detection of DDB1.
主要应用	Western Blotting
应用说明	Produced in collaboration with Epitomics™

生物信息
免疫原品种	Synthetic peptide corresponding to human DDB1.
克隆	EPR6088
浓缩	Please refer to lot specific datasheet.
宿主	Rabbit
同种型	IgG
品种反应性	MouseHuman
Species Reactivity Note	Human, Mouse
抗体类型	Monoclonal Antibody
基因符号	XAP1 DDB1
纯化方法	Unpurified
UniProt编号	Q16531

产品使用声明
质量保证	Evaluated by Western Blotting in HeLa, HepG2, NIH/3T3, and Jurkat cell lysates. Western Blotting Analysis: A 1:10,000-50,000 dilution of this antibody detected DDB1 in HeLa, HepG2, NIH/3T3, and Jurkat cell lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.