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经验配方 CAS号 C₂₆H₂₁N₃O₄ •0.5H₂O •0.5C₃H₈O 111358-88-4 描述 概述 A cell-permeable indolocarbazole that is reported to inhibit the activity of several tyrosine kinases, including JAK2/3, Flt3, TrkA, Flk1/KDR/VEGFR2, (IC50 = 0.9, 3, 3.4, and 65 nM, respectively, in cell-free kinase assays) and RET, while exhibiting much reduced potency against PKC and PDGFRβ (IC50 = 218 and 773 nM, respectively) and little or no effect towards EGFR, βIRK, FMS, KIT, or Bcr-Abl. CEP-701 is shown to exhibit anti-cancer efficacy in numerous cultures in vitro as well as in murine and rat xenograft models via subcutaneous or oral dosage (10 to 30 mg/kg, b.i.d.) in vivo. 产品目录编号 219499 品牌系列 Calbiochem®
同义词 KT-5555, VEGFR Tyrosine Kinase Inhibitor XXXIII, VEGFR2 Kinase Inhibitor XXXI, JAK2 Inhibitor VIII, JAK3 Inhibitor IX, PDGFR Tyrosine Kinase Inhibitor XX 参考 参考 Hexner, E.O., et al. 2008. Blood 111, 5663.
Strock, C.J., 2003. Cancer Res. 63, 5559.
Zheng, R., et al. 2002. Blood 100, 4154.
Levis, M., et al. 2002. Blood 99, 3885.
Miknyoczki, S.J., et al. 1999. Clin. Cancer Res. 5, 2205.
Miknyoczki, S.J., et al. 1999. Ann. N.Y. Acad. Sci. 880, 252.
George, D.J., et al. 1999. Cancer Res. 59, 2395.产品信息 CAS号 111358-88-4 形式 Off-white solid Hill配方 C₂₆H₂₁N₃O₄ •0.5H₂O •0.5C₃H₈O 化学配方 C₂₆H₂₁N₃O₄ •0.5H₂O •0.5C₃H₈O Molar Mass 478.6 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Regulatory Review
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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