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merck millipore,默克密理博,07-2177,Anti-phospho-PKD2 Antibody (Ser197/Ser200)
产品名称：Anti-phospho-PKD2 Antibody (Ser197/Ser200)
产品型号：07-2177
This phospho-PKD2 antibody is validated for use in WB for the detection of the phospho-PKD2 protein.
merck millipore,默克密理博,07-2177,Anti-phospho-PKD2 Antibody (Ser197/Ser200)
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-2177 描述 Anti-phospho-PKD2 Antibody (Ser197/Ser200) Alternate Names - R48321
- Autosomal dominant polycystic kidney disease type II protein
- Polycystic kidney disease 2 protein
- Polycystwin
背景信息 As members of the calcium-/calmodulin-depedent protein kinase superfamily, there are three known Protein Kinase D (PKD) isoforms, PKD1, PKD2, and PKD3. These serine/threonine kinases are involved in protein-protein and protein-carbohydrate adhesion and are also thought to be ion channel regulators. They are prominent downstream targets of protein kinase C and phospholipase D in various biological systems including mouse. PKDs are activated by various stimuli, including phorbol esters, G-protein-coupled receptors, reactive oxygen species, and diacylglycerol. PKDs regulate protein transport in the trans-Golgi network and are thought to play a role in muscle differentiation, cell motility, migration, and invasion. These isoforms are known to interact with each other. PKD2 is shown to be activated by phorbol esters, both in vivo and in vitro, and also by gastrin via the cholescystokinin/CCK(B) receptor in stably-transfected AGS-B cells. Furthermore, PKD2 is found to be active during the early phase of differentation of C2C12 cells into skeletal muscle cells. It is also reported to enhance TCR-induced NFAT activity in Jurkat T cells. 产品信息 格式 Affinity Purified 控制 - MEF cell lysates untreated and PBDu-treated
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This phospho-PKD2 antibody is validated for use in WB for the detection of the phospho-PKD2 protein. 主要应用 - Western Blotting
应用说明 Evaluated by Western Blot in MEF cell lysates untreated and treated with PDBu, Rapamycin, and GO6983.
Western Blot Analysis: A 1:2,000 dilution of this antibody detected PKD2 in 10 µg of MEF cell lysates untreated and treated with PDBu, Rapamycin, and GO6983.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human PKD2 phosphorylated at Ser197/Ser200. 表位 Phosphorylated Ser197/Ser200 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes PKD2 phosphorylated at Ser197/Ser200. 品种反应性 RatMouseHuman Species Reactivity Note Demonstrated to react with Mouse.
Predicted to react with Human and Rat based on 100% sequence homology.抗体类型 Polyclonal Antibody Entrez基因编号 - NP_000288
Entrez基因汇总 This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. 基因符号 - MGC138468
- PC2
- PKD4
- Pc-2
- APKD2
- TRPP2
- MGC138466
修改 - Phosphorylation
纯化方法 Affinity Purified UniProt编号 - Q13563
UniProt汇总 FUNCTION: Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis.
SUBUNIT STRUCTURE: Forms homooligomers. Interacts with PKD1. PKD1 requires the presence of PKD2 for stable expression. Interacts with CD2AP. Interacts with HAX1.
SUBCELLULAR LOCATION: Multi-pass membrane protein Potential. Endoplasmic reticulum.产品使用声明 质量保证 Evaluated by Western Blot in MEF cell lysates untreated and PBDu-treated.
Western Blot Analysis: A 1:2,000 dilution of this antibody detected PKD2 in 10 µg of MEF cell lysates untreated and PBDu-treated.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,219499,CEP-701 - CAS 111358-88-4 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,324842,EGFR/ErbB-2/ErbB-4 Inhibitor II - CAS 944341-54-2 - Calbiochem
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