merck millipore,默克密理博,324842,EGFR/ErbB-2/ErbB-4 Inhibitor II - CAS 944341-54-2

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Merck Millipore 默克密理愽

merck millipore,默克密理博,324842,EGFR/ErbB-2/ErbB-4 Inhibitor II - CAS 944341-54-2 - Calbiochem

经验配方	CAS号
C₂₄H₂₇ClN₆O₃ • HCl	944341-54-2

描述
概述	A cell-permeable aminopyrimidine oxime compound that potently inhibits EGFR/ErbB1/HER1, ErbB2/HER2/neu, and ErbB4/HER4 kinase activity (IC₅₀ = 22, 38 and 21 nM, respectively) in an ATP-competitive manner and effectively suppresses cellular receptor phosphorylation (IC₅₀ = 223 and 107 nM against basal HER2 and EGF-induced EFGR phosphorylation, respectively, in SKBR3 and A431 cultures) as well as HER2- and EGFR-dependent cancer cell proliferations (IC₅₀ <1µM), while exhibiting much reduced or little activity against a panel of 202 other kniases. Reported to be orally available and blood-brain barrier permeant in both mice and rats and be efficacious in inhibiting tumor growth in several murine xenograft models (100 to 200 mg/kg/day, p.o.) in vivo.
产品目录编号	324842
品牌系列	Calbiochem®
同义词	(E)-4-Amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde-O-(2-morpholin-4-yl-ethyl)-oxime, HCl, JNJ-28871063, HCl
应用数据

参考
参考	Emanuel, S.L., et al. 2008. Mol. Pharmacol. 73, 338.

生物信息
纯度	≥95% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,324842,EGFR/ErbB-2/ErbB-4 Inhibitor II - CAS 944341-54-2 - Calbiochem

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