merck millipore,默克密理愽
  • merck millipore,默克密理博,14-649M,DMPK Protein, active, 250 µg

  • merck millipore,默克密理博,14-649M,DMPK Protein, active, 250 µg

    产品名称：DMPK Protein, active, 250 µg
    产品型号：14-649M
    Active, 6His-tagged, recombinant, human DMPK, amino acids 1-549, for use in Kinase Assays.

    merck millipore,默克密理博,14-649M,DMPK Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-649M,DMPK Protein, active, 250 µg

    描述
    产品目录编号 14-649M
    品牌系列 Upstate
    商名
    • Upstate
    描述 DMPK Protein, active, 250 µg
    概述 6His-tagged, recombinant, human DMPK, amino acids 1-549
    应用
    应用 Active, 6His-tagged, recombinant, human DMPK, amino acids 1-549, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed by baculovirus in Sf21 cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_004409.3
    • NM_001081560.1
    • NM_001081562.1
    • NM_001081563.1
    Entrez基因汇总 The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
    基因符号
    • DM1PK
    • DMPK
    • DM-kinase
    • MDPK
    • MT-PK
    • DM
    • DM1
    • DMK
    蛋白靶 DMPK
    纯化方法 Ni2+/NTA-agarose
    靶子系列 AGC
    UniProt编号
    • Q09013
    UniProt汇总 FUNCTION: SwissProt: Q09013 # Critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity. Phosphorylates phospholamban.
    COFACTOR: Magnesium.
    SIZE: 639 amino acids; 70357 Da
    TISSUE SPECIFICITY: Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons.
    DISEASE: SwissProt: Q09013 # Defects in DMPK are the cause of myotonic dystrophy 1 (DM1) [MIM:160900]; also known as Steinert disease. DM is an autosomal dominant neurodegenerative disorder characterized by myotonia, muscle wasting in the distal extremities, cataract, hypogonadism, defective endocrine functions, male baldness, and cardiac arrhythmias. DM patients show decreased levels of kinase expression inversely related to repeat length. The minimum estimated incidence is 1 in 8'000 live births. DM1 is caused by a CTG expansion in the 3'-UTR of the DMPK gene. The repeat length usually increases in successive generations, but not always.
    SIMILARITY: SwissProt: Q09013 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of Axltide (12-516)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-649) and in bulk (cat# 14-649-K).

    merck millipore,默克密理博,14-649M,DMPK Protein, active, 250 µg

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