merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE327,Anti-p53 (pantropic) Antibody, clone DO-1

  • merck millipore,默克密理博,MABE327,Anti-p53 (pantropic) Antibody, clone DO-1

    产品名称：Anti-p53 (pantropic) Antibody, clone DO-1
    产品型号：MABE327
    Use Anti-p53 (pantropic) Antibody, clone DO-1 (Mouse Monoclonal Antibody) validated in WB, ICC, IHC, IF, IP to detect p53 (pantropic) also known as Cellular tumor antigen p53 or Antigen NY-CO-13.

    merck millipore,默克密理博,MABE327,Anti-p53 (pantropic) Antibody, clone DO-1

  • 产品介绍
  • merck millipore,默克密理博,MABE327,Anti-p53 (pantropic) Antibody, clone DO-1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE327
    Replaces 04-1083
    描述 Anti-p53 (pantropic) Antibody, clone DO-1
    Alternate Names
    • Tumor suppressor p53
    • Cellular tumor antigen p53
    • Antigen NY-CO-13
    • Phosphoprotein p53
    背景信息 Cellular tumor antigen p53 (p53) is a ubiquitous transcription factor that is most widely known for its function as a tumor suppressor, through its regulation of cell growth and survival. p53 is activated in response to cell stress such as DNA damage and induces either cell cycle arrest or apoptosis. It coordinates the expression of multiple genes including p21, GADD45, Bax, and Puma. p53 is regulated by multiple mechanisms: At the post-transcriptional level, the stability of p53 mRNAs is regulated by the binding of molecules such as HuR, Wig-1, RPL26, L26, and WRAP53. Post-translationally, p53 undergoes phosphorylation and acetylation which may also play a role in regulating its activity. It may also undergo ubiquitination via the Akt-MDM2 pathway resulting in degradation by the 20S proteosome. Mutations in p53 are prevalent in many types of cancers, underscoring the therapeutic relevance of this protein.
    产品信息
    格式 Purified
    控制
    • A431 cell lysate
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-p53 (pantropic) Antibody, clone DO-1 (Mouse Monoclonal Antibody) validated in WB, ICC, IHC, IF, IP to detect p53 (pantropic) also known as Cellular tumor antigen p53 or Antigen NY-CO-13.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    应用说明 Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected p53 (pantropic) in A431 cells.

    Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected p53 (pantropic) in human colorectal adenocarcinoma tissue and in human prostate cancer tissue.

    Immunofluorescence Analysis: A 1:1,000 dilution from a representative lot detected p53 (pantropic) in human colorectal cancer cells.

    Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in radiolabelled HOS cell lysate (Vojtesek, B., et al. (1995). 71(6):1253-1256.).

    Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in primary breast carcinoma tissue (Beck, T., et al. (1995). Gynecol Oncol. 57(1):96-104.).
    生物信息
    免疫原品种 Recombinant protein corresponding to human p53 (pantropic).
    表位 N-terminus
    克隆 DO-1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes the N-terminus of p53 (pantropic).
    同种型 IgG2aκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_000537
    Entrez基因汇总 This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.
    基因符号
    • P53
    • TP53
    纯化方法 Protein G purified
    UniProt编号
    • P04637
    产品使用声明
    质量保证 Evaluated by Western Blot in A431 cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected p53 (pantropic) in 10 µg of A431 cell lysate. This antibody detects isoforms 1, 2, and 3.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABE327,Anti-p53 (pantropic) Antibody, clone DO-1

上一件merck millipore产品：merck millipore,默克密理博,AP114F-K,Goat Anti-Human IgM, Affinity Purified, Fluorescein Conjugated (1mg)
下一件merck millipore产品：merck millipore,默克密理博,SF-755,ATG9B; Human, Cyanine 5, RNA Detection Probe,SmartFlare


相关产品

merck millipore,默克密理博,220485,Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem merck millipore,默克密理博,220485,Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem

merck millipore,默克密理博,06-543,Anti-FAK Antibody merck millipore,默克密理博,06-543,Anti-FAK Antibody

merck millipore,默克密理博,234149,Collagen, Type I, Human Placenta merck millipore,默克密理博,234149,Collagen, Type I, Human Placenta

merck millipore,默克密理博,527962,Pimaricin, Streptomyces chattanoogensis - CAS 7681-93-8 - Calbiochem merck millipore,默克密理博,527962,Pimaricin, Streptomyces chattanoogensis - CAS 7681-93-8 - Calbiochem

merck millipore,默克密理博,AP114F-K,Goat Anti-Human IgM, Affinity Purified, Fluorescein Conjugated (1mg) merck millipore,默克密理博,AP114F-K,Goat Anti-Human IgM, Affinity Purified, Fluorescein Conjugated (1mg)

merck millipore,默克密理博,SF-755,ATG9B; Human, Cyanine 5, RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-755,ATG9B; Human, Cyanine 5, RNA Detection Probe,SmartFlare

merck millipore,默克密理博,05-1566,Anti-Septin-6 Antibody, clone 9E7 merck millipore,默克密理博,05-1566,Anti-Septin-6 Antibody, clone 9E7

merck millipore,默克密理博,AB15860,Anti-Histamine Receptor 3 (HR3) Antibody merck millipore,默克密理博,AB15860,Anti-Histamine Receptor 3 (HR3) Antibody

merck millipore,默克密理博,07-1596,Anti-SIRT3 (CT) Antibody merck millipore,默克密理博,07-1596,Anti-SIRT3 (CT) Antibody

merck millipore,默克密理博,GF438,HumanKine SCF, Human Recombinant Xeno-Free merck millipore,默克密理博,GF438,HumanKine SCF, Human Recombinant Xeno-Free


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部