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merck millipore,默克密理博,220485,Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem
产品名称：Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem
产品型号：220485
The Chk2 Inhibitor, also referenced under CAS 724708-21-8, controls the biological activity of Chk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation application More>>
merck millipore,默克密理博,220485,Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₅H₁₃N₅O₂ 724708-21-8 描述 概述 A cell-permeable, ATP competitive, and reversible indoloazepine compound that displays anti-proliferative and anti-inflammatory properties. Acts as a potent inhibitor of Chk2 (IC50 = 8 nM) that targets the ATP binding pocket. Exhibits selectivity for Chk2 over MEK1, Chk1, CK1δ, PKCα, PKCβII and CK2 (IC50 = 89 nM, 237 nM, 1.352 µM, 2.539 µM, 3.381 µM, and > 10.0 µM, respectively). Blocks the production of IL-2 and TNF-α by preventing the transcriptional activation of NF-κB (IC50 = 3.55 µM for IL-2 production in PMA-stimulated Jurkat T cells; 8.16 µM for TNF-α production in LPS-stimulated THP-1 cells). Also reported to suppress the growth of leukemic T cells (GI50 = 1.73 µM). 产品目录编号 220485 品牌系列 Calbiochem®
同义词 5-(2-Amino-5-oxo-1,5-dihydroimidazol-4-ylidine)-3,4,5,10-2H-azepino[3,4-b]indol-1-one, Chk1 Inhibitor II, Chk2 Inhibitor I 参考 参考 Sharma, V., and Tepe, J.J. 2004. Bioorg. Med. Chem. Lett. 14, 4319.
Sharma, V., et al. 2004. J. Med. Chem. 47, 3700.产品信息 CAS号 724708-21-8 具有ATP竞争性 Y 声明 Sold under license from Michigan State University. 形式 Pale yellow solid Hill配方 C₁₅H₁₃N₅O₂ 化学配方 C₁₅H₁₃N₅O₂ Molar Mass 295.3 吸湿 Hygroscopic
可逆 Y 结构配方图像 生物信息 主靶 Chk2 主靶IC50 8 nM against Chk2 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Carcinogenic / Teratogenic
储存 -20°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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