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  • merck millipore,默克密理博,AB15860,Anti-Histamine Receptor 3 (HR3) Antibody

  • merck millipore,默克密理博,AB15860,Anti-Histamine Receptor 3 (HR3) Antibody

    产品名称：Anti-Histamine Receptor 3 (HR3) Antibody
    产品型号：AB15860
    Anti-Histamine Receptor 3 (HR3) Antibody is an antibody against Histamine Receptor 3 (HR3) for use in WB.

    merck millipore,默克密理博,AB15860,Anti-Histamine Receptor 3 (HR3) Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB15860,Anti-Histamine Receptor 3 (HR3) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB15860
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Histamine Receptor 3 (HR3) Antibody
    产品信息
    格式 Affinity Purified
    演示 Liquid in PBS with 0.1% sodium azide.
    应用
    应用 Anti-Histamine Receptor 3 (HR3) Antibody is an antibody against Histamine Receptor 3 (HR3) for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Synthetic peptide from rat Histamine Receptor 3.
    宿主 Rabbit
    特异性 Histamine Receptor 3 (HR3). By Western blot the antibody reacts with a band at ~ 50 kDa on rat brain lysate. An additional band at ~ 145 kDa may be seen depending on sample and antibody concentration used.
    品种反应性 Rat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_007232.1
    Entrez基因汇总 Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H3 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system.
    基因符号
    • HH3R
    • HRH3
    • GPCR97
    UniProt编号
    • Q9Y5N1
    UniProt汇总 FUNCTION: SwissProt: Q9Y5N1 # The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 niether modified adenylate cyclase activity nor induced intracellular calcium mobilization.
    SIZE: 445 amino acids; 48671 Da
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.
    SIMILARITY: SwissProt: Q9Y5N1 ## Belongs to the G-protein coupled receptor 1 family.
    MISCELLANEOUS: Does not bind to cimetidine and tripolidine. Shows modest affinity for thioperamide, imetit, N-alpha-methylhistamine and R(-)-alpha-methylhistamine. Isoform 4 is unable to bind to iodoproxyfan while isoforms 1 and 3 bind it with high affinity.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
    包装信息
    数量 1

    merck millipore,默克密理博,AB15860,Anti-Histamine Receptor 3 (HR3) Antibody

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