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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC114 描述 Anti-Thrombospondin-2 Antibody Alternate Names - Thrombospondin-2
背景信息 Thrombospondins (TSPs) are a family of homotrimeric multi-domain glycoproteins involved in modulation of cell adhesion, proliferation, and migration and have been implicated clinically in the development of atherosclerosis, angiogenesis, and oncogenesis. TSP2, a member of the thrombospondin family is a secreted protein, but is present only transiently in extracellular matrix and is rapidly internalized for degradation by fibroblasts after binding to the cell surface. It also interacts with matrix metalloproteinases (MMPs) and matrix serine proteases, such as plasminogen activator. TSP2 is reportedly controls the apoptosis-proliferation balance in endothelial cells. Although TSP2 is a potent inhibitor of angiogenesis, its N-terminal region exhibits pro-angiogenic activities mediated by beta 1 integrins. Loss of TSP2 expression is associated with local invasive behavior, tumor neovascularization, and metastasis. Decreased TSP2 expression has been correlated with malignant progression and angiogenesis in some cancers. TSP2 levels are also highly expressed in developing and healing tissues. 产品信息 格式 Affinity Purified 控制 - Concentrated conditioned media from MG-63 cells
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Thrombospondin-2 Antibody is an antibody against Thrombospondin-2 for use in Western Blotting. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the Laminin G-like region of human Thrombospondin-2. 表位 Laminin G-like region 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the Laminin G-like region of Thrombospondin-2. 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. Predicted to react with Chimpanzee based on 100% sequence homology. Other homologies: Mouse, Rat, and Bovine (93% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003238
基因符号 - TSP2
- THBS2
纯化方法 Affinity purified UniProt编号 - P35442
产品使用声明 质量保证 Evaluated by Western Blot in concentrated conditioned media from MG-63 cells.
Western Blot Analysis: 0.25 µg/mL of this antibody detected Thrombospondin-2 in 10 µg of concentrated conditioned media from MG-63 cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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