merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1566,Anti-Septin-6 Antibody, clone 9E7

  • merck millipore,默克密理博,05-1566,Anti-Septin-6 Antibody, clone 9E7

    产品名称：Anti-Septin-6 Antibody, clone 9E7
    产品型号：05-1566
    Anti-Septin-6 Antibody, clone 9E7 is a Mouse Monoclonal Antibody for the detection of Septin-6 & has been validated in WB & IP.

    merck millipore,默克密理博,05-1566,Anti-Septin-6 Antibody, clone 9E7

  • 产品介绍
  • merck millipore,默克密理博,05-1566,Anti-Septin-6 Antibody, clone 9E7

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Ca, HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1566
    描述 Anti-Septin-6 Antibody, clone 9E7
    Alternate Names
    • septin 2
    • septin 6
    背景信息 Septin-6 is a filament-forming GTPase that participates in cytokenisis and is necessary for the normal organization of the actin cytoskeleton. It is widely expressed in tissues and is found in the cytoplasm and in the spindle during metaphase. Four isoforms of Septin-6 have been described.
    As a protein family Septins were first characterized as regulators of cytokinesis. These proteins were later shown to have a broader role in microtubule-dependent processes, such as karyokinesis, exocytosis, and maintenance of cell shape. Several septin family members are known to colocalize or interact with the microtubule cytoskeleton and are believed to play a role in regulating microtubule dynamics through interactions with microtubule-associated proteins (MAPs).
    产品信息
    格式 Purified
    控制
    • HeLa cell lysate
    演示 Purified mouse monoclonal IgG3κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Anti-Septin-6 Antibody, clone 9E7 is a Mouse Monoclonal Antibody for the detection of Septin-6 & has been validated in WB & IP.
    主要应用
    • Western Blotting
    应用说明 Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP. (Kremer, B., et al. (2005). MBC. 16(10):4648-4659.)
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to human Septin-6.
    表位 Unknown
    克隆 9E7
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes Septin-6.
    同种型 IgG3κ
    品种反应性 CanineHuman
    Species Reactivity Note Demonstrated to react with human. Predicted to react with canine based on 100% sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_055944
    Entrez基因汇总 This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq].
    基因符号
    • SEPT2
    • SEPT6
    • KIAA0128
    • SEP2
    纯化方法 Protein G purfied
    UniProt编号
    • Q14141
    UniProt汇总 FUNCTION: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication.

    SUBUNIT STRUCTURE: Septins polymerize into hetero-oligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT2 and SEPT7. Also interacts with SEPT9 and SEPT12. Interaction with SEPT12 alters filament structure. Interacts with SOCS7. Interacts with HCV NS5B and with HNRNPA1.

    SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm › cytoskeleton › spindle. Note: In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle.

    TISSUE SPECIFICITY: Widely expressed.

    PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.

    MISCELLANEOUS: Coordinated expression with SEPT2 and SEPT7.

    SEQUENCE SIMLARITIES: Belongs to the septin family.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate.

    Western Blot Analysis: 0.1 µg/ml of this antibody detected Septin-6 on 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,05-1566,Anti-Septin-6 Antibody, clone 9E7

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