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merck millipore,默克密理博,MABE241,Anti-dimethyl-phospho Histone H3 (Lys9/27)/(Ser10/28) Antibody, clone 51TA-2H12
产品名称：Anti-dimethyl-phospho Histone H3 (Lys9/27)/(Ser10/28) Antibody, clone 51TA-2H12
产品型号：MABE241
Anti-dimethyl-phospho Histone H3 (Lys9/27)/(Ser10/28) Antibody, clone 51TA-2H12 is a Mouse Monoclonal Antibody for detection of dimethyl-phospho Histone H3 (Lys9/27)/(Ser10/28) also known as Histone H More>>
merck millipore,默克密理博,MABE241,Anti-dimethyl-phospho Histone H3 (Lys9/27)/(Ser10/28) Antibody, clone 51TA-2H12
- 产品介绍
- merck millipore,默克密理博,MABE241,Anti-dimethyl-phospho Histone H3 (Lys9/27)/(Ser10/28) Antibody, clone 51TA-2H12
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB, ICC M Ascites Monoclonal Antibody 描述 产品目录编号 MABE241 描述 Anti-dimethyl-phospho Histone H3 (Lys9/27)/(Ser10/28) Antibody, clone 51TA-2H12 Alternate Names - Histone H3/l
- Histone H3.1
- Histone H3/a
- Histone H3/b
- Histone H3/c
- Histone H3/d
- Histone H3/f
- Histone H3/h
- Histone H3/I
- Histone H3/j
- Histone H3/k
背景信息 Histones are nuclear proteins that form octameric structures which bind DNA to form units of chromatin called nucleosomes. The family of histones—H2A, H2B, H3, and H4—are key players in gene regulation. They undergo a number of post-translational modifications (PTM) in response to various stimuli, including phosphorylation on serine and threonine residues and methylation on lysine residues. PTMs produce configural changes in histone proteins that may induce nucleosome remodeling and expose or hide DNA sequences from transcriptional complexes. Methylation occurs on histone H3 at lysine 4, 9, 27, 36, and 79 residues. Previous studies have reported that methylation of H3 lysine 9 provides a binding site for heterochromatin adaptor proteins (HP1) which are involved in the formation of heterochromatin and gene repression. Conversely,deacetylation of histone H3 lysine 9 is associated with gene-activating events. Often, it is the pattern of different modifications on several histone residues that alter chromatin, rather than modification of single residues. 产品信息 格式 Ascites 控制 - Untreated and etoposide acid extract treated HeLa cell lysates.
演示 Mouse monoclonal IgG1κ ascites with 0.05% sodium azide. 应用 应用 Anti-dimethyl-phospho Histone H3 (Lys9/27)/(Ser10/28) Antibody, clone 51TA-2H12 is a Mouse Monoclonal Antibody for detection of dimethyl-phospho Histone H3 (Lys9/27)/(Ser10/28) also known as Histone H3.1 & has been validated in WB, DB, ICC, IP & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
应用说明 Western Blot Analysis: A representative lot was used by an independent laboratory in KCl whole-cell extract. (Eberlin, A., et al. (2008). Molecular and Cellular Biology. 28(5):1739–1754.)
Dot Blot Analysis: A representative lot was used by an independent laboratory in unmodified and modified Histone H3 peptides. (Eberlin, A., et al. (2008). Molecular and Cellular Biology. 28(5):1739–1754.)
Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in NIH/3T3 cells. (Eberlin, A., et al. (2008). Molecular and Cellular Biology. 28(5):1739–1754.)
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in mouse testis tissue. (Eberlin, A., et al. (2008). Molecular and Cellular Biology. 28(5):1739–1754.)
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in HeLa cells. (Eberlin, A., et al. (2008). Molecular and Cellular Biology. 28(5):1739–1754.)生物信息 免疫原品种 Ovalbumin-conjugated linear peptide corresponding to human Histone H3 dimethylated and phosphorylated at Lys9/27 and Ser10/28. 表位 Dimethylated and phosphorylated at Lys9/27 and Ser10/28. 克隆 51TA-2H1 宿主 Mouse 特异性 This antibody recognizes Histone H3 dimethylated and phosphorylated at Lys9/27 and Ser10/28. 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_003520
基因符号 - H3FJ
- HIST1H3A
- H3FA
- HIST1H3B
- H3FL
- HIST1H3C
- H3FC
- HIST1H3D
- H3FB
- HIST1H3E
- HIST1H3F
- H3FI
- HIST1H3G
- H3FH
- HIST1H3H
- H3FK
- HIST1H3I
- H3FF
- HIST1H3J
纯化方法 Unpurified UniProt编号 - P68431
产品使用声明 质量保证 Evaluated by Western Blot in untreated and etoposide acid extract treated HeLa cell lysates.
Western Blot Analysis: A 1:5,000 dilution of this antibody detected Histone H3 on 10 µg of untreated and etoposide acid extract treated HeLa cell lysates.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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