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merck millipore,默克密理博,MABF413,Anti-CD3 (mouse) Antibody, AlexaFluor647, clone 17A2
产品名称：Anti-CD3 (mouse) Antibody, AlexaFluor647, clone 17A2
产品型号：MABF413
Anti-CD3 (mouse) Antibody, AlexaFluor647, clone 17A2 is a highly specific rat monoclonal antibody, that targets CD3 & has been tested in Flow Cytometry, IHC, Activity Assay & IP.
merck millipore,默克密理博,MABF413,Anti-CD3 (mouse) Antibody, AlexaFluor647, clone 17A2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M ACT, FC, IHC R AlexaFluor®647 Monoclonal Antibody 描述 产品目录编号 MABF413 描述 Anti-CD3 (mouse) Antibody, AlexaFluor®647, clone 17A2 Alternate Names - CD3
- T-cell surface glycoprotein CD3 epsilon chain
- T-cell surface antigen T3/Leu-4 epsilon chain
背景信息 CD3, also known as T3, is a member of the Ig and the ITAM superfamilies. The CD3 complex is composed of six polypeptides with usually four different transmembrane CD3 chains, gamma, delta, epsilon and zeta. CD3 is primarily expressed on T cells, NK-T cells, and at different levels on thymocytes during T cell differentiation. CD3 plays a critical role in TCR signal transduction, T cell activation, and antigen recognition by binding the peptide/MHC antigen complex. The CD3 antigen is present in early thymocytes, and has been considered the best all-around T cell marker. The positive staining of this marker may represent a sign of early commitment to the T cell lineage. In cortical thymocytes, during early stages of maturation, the CD3 antigen is predominantly present in the cell cytoplasm. In medullary thymocyles, the CD3 antigen is predominantly detected on the cell surface. The majority of T cell neoplasms also expresses CD3, but it is absent from non-T-cell lymphoid malignancies. CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. 产品信息 格式 AlexaFluor®647 演示 Purified rat conjugate antibody in buffer containing PBS (pH 7.2) with up to 0.1% sodium azide. 应用 应用 Anti-CD3 (mouse) Antibody, AlexaFluor®647, clone 17A2 is a highly specific rat monoclonal antibody, that targets CD3 & has been tested in Flow Cytometry, IHC, Activity Assay & IP. 主要应用 - Activity Assay
- Flow Cytometry
- Immunohistochemistry
应用说明 Immunohistochemistry Analysis: A previous lot detected human CD3 in Immunohistochemistry. (Zhang Y, et al. 2002; Miescher GC, et al. 1989.)
Immunoprecipitation Analysis: A previous lot detected human CD3 in Immunoprecipitation. (Miescher GC, et al. 1989.)
Activity Assay Analysis: A previous lot detected human CD3 in Activity Assay. (Miescher GC, et al. 1989.)
生物信息 免疫原品种 γδTCR-positive T-T hybridoma D1 克隆 17A2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 特异性 This antibody recognizes ε/γ (but not ε/δ) of the CD3 complex. 同种型 IgG2bκ 品种反应性 Mouse Species Reactivity Note Mouse 抗体类型 Monoclonal Antibody 基因符号 - Cd3
纯化方法 Affinity UniProt编号 - P22646
产品使用声明 质量保证 The antibody was purified by affinity chromatography, and conjugated with AlexaFluor®647 under optimal conditions. The solution is free of unconjugated AlexaFluor®647 and unconjugated antibody. Alexa Fluor® 647 is a registered trademark of Molecular Probes, Inc. Alexa Fluor® 647 dye antibody conjugates are sold under license from Molecular Probes, Inc. for research use only, except for use in combination with microarrays and high content screening, and are covered by pending and issued patents.
Flow Cytometry Analysis: 0.25 μg of this antibody detected CD3 in one million C57BL/6 mouse splenocytes.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
包装信息 数量 100 µg
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